Compile Data Set for Download or QSAR
Found 1518 of ic50 data for polymerid = 3579
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50393099(CHEMBL2152914 | US10231967, Example 122 | US991898...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM41537(US10231967, Example 114 | US8865911, 114 | US99189...)copy SMILEScopy InChI
Affinity DataIC50: 0.140nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM369585(US10231967, Example 94-Isomer-1)copy SMILEScopy InChI
Affinity DataIC50: 0.170nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50393100(CHEMBL2152915 | US10231967, Example 125 | US991898...)copy SMILEScopy InChI
Affinity DataIC50: 0.260nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136856(US10231967, Example 92-Isomer-1 | US8865911, 92 Is...)copy SMILEScopy InChI
Affinity DataIC50: 0.270nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50393099(CHEMBL2152914 | US10231967, Example 122 | US991898...)copy SMILEScopy InChI
Affinity DataIC50: 0.280nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50220297(1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-(3,5-diflu...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane Abeta40 levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0KZBPubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50393099(CHEMBL2152914 | US10231967, Example 122 | US991898...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50393102(CHEMBL2152917 | US10231967, Example 20t | US886591...)copy SMILEScopy InChI
Affinity DataIC50: 0.360nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM369555(US10231967, Example 68-Isomer-1)copy SMILEScopy InChI
Affinity DataIC50: 0.380nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50393100(CHEMBL2152915 | US10231967, Example 125 | US991898...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136858(US10231967, Example 93 | US8865911, 93 | US8865911...)copy SMILEScopy InChI
Affinity DataIC50: 0.560nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50393102(CHEMBL2152917 | US10231967, Example 20t | US886591...)copy SMILEScopy InChI
Affinity DataIC50: 0.560nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136739(US10231967, Example 119 | US8865911, 20e | US99189...)copy SMILEScopy InChI
Affinity DataIC50: 0.570nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136863(US10231967, Example 100 | US8865911, 100 | US99189...)copy SMILEScopy InChI
Affinity DataIC50: 0.590nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136761(US10231967, Example 20u | US8865911, 20u | US90001...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TH8KDPUS Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136854(US10231967, Example 91 | US8865911, 91 | US9918985...)copy SMILEScopy InChI
Affinity DataIC50: 0.620nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136761(US10231967, Example 20u | US8865911, 20u | US90001...)copy SMILEScopy InChI
Affinity DataIC50: 0.630nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50393100(CHEMBL2152915 | US10231967, Example 125 | US991898...)copy SMILEScopy InChI
Affinity DataIC50: 0.630nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136739(US10231967, Example 119 | US8865911, 20e | US99189...)copy SMILEScopy InChI
Affinity DataIC50: 0.670nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM369525(US10231967, Example 48-Isomer-1 | US9918985, Examp...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM155101(US9000182, 11, isomer 1)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TH8KDPUS Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM155100(US9000182, 9, isomer 1)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TH8KDPUS Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM369585(US10231967, Example 94-Isomer-1)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50393100(CHEMBL2152915 | US10231967, Example 125 | US991898...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136863(US10231967, Example 100 | US8865911, 100 | US99189...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50393104(CHEMBL2152918 | US10231967, Example 20aa | US99189...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50393106(CHEMBL2152920 | US10231967, Example 72 | US9918985...)copy SMILEScopy InChI
Affinity DataIC50: 0.760nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136736(US10231967, Example 20b | US8865911, 20b | US99189...)copy SMILEScopy InChI
Affinity DataIC50: 0.780nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM155152(US9000185, 8)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FB51QTUS Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM155120(US9000183, 6 Isomer 1)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PR7TQDUS Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136848(US10231967, Example 85 | US8865911, 85 | US9918985...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136830(US10231967, Example 67 | US8865911, 67 | US8865911...)copy SMILEScopy InChI
Affinity DataIC50: 0.810nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136861(US10231967, Example 98 | US8865911, 98 | US9918985...)copy SMILEScopy InChI
Affinity DataIC50: 0.820nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136856(US10231967, Example 92-Isomer-1 | US8865911, 92 Is...)copy SMILEScopy InChI
Affinity DataIC50: 0.840nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136913(US10231967, Example 135 | US8865911, 135 | US99189...)copy SMILEScopy InChI
Affinity DataIC50: 0.850nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM155147(US9000185, 4, isomer 1)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FB51QTUS Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136850(US10231967, Example 87 | US8865911, 87 | US9918985...)copy SMILEScopy InChI
Affinity DataIC50: 0.930nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136739(US10231967, Example 119 | US8865911, 20e | US99189...)copy SMILEScopy InChI
Affinity DataIC50: 0.970nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136847(US10231967, Example 84 | US8865911, 84 | US9918985...)copy SMILEScopy InChI
Affinity DataIC50: 0.990nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM369599(3-[(1r,4r)-4″-Amino-4-(difluoromethoxy)-5...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136833(US10231967, Example 73 | US8865911, 73 | US9000182...)copy SMILEScopy InChI
Affinity DataIC50: 1nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TH8KDPUS Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50583320(CHEMBL5084378)copy SMILES
Affinity DataIC50: 1nMAssay Description:Inhibition of human amyloid beta (1 to 42) in human SKNBE2 cells expressing wild-type amyloid precursor protein hAPP695 incubated for 18 hrs by sandw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5S2JPubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM103948(US8569521, 144)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DR2T4DUS Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM155133(US9000184, 6, isomer 1)copy SMILEScopy InChI
Affinity DataIC50: 1nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K35SDQUS Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136833(US10231967, Example 73 | US8865911, 73 | US9000182...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM50583322(CHEMBL5093303)copy SMILES
Affinity DataIC50: 1nMAssay Description:Inhibition of human amyloid beta (1 to 42) in human SKNBE2 cells expressing wild-type amyloid precursor protein hAPP695 incubated for 18 hrs by sandw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5S2JPubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136739(US10231967, Example 119 | US8865911, 20e | US99189...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM369599(3-[(1r,4r)-4″-Amino-4-(difluoromethoxy)-5...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Universita degli Studi di Bari

LigandPNGBDBM136849(US10231967, Example 86 | US8865911, 86 | US9918985...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RF5X91US Patent
Displayed 1 to 50 (of 1518 total ) | Next | Last >>
Jump to: