Compile Data Set for Download or QSAR

Found 81 hits of Enzyme Inhibition Constant Data   

TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50272453(2-((R)-1-(3,4-dichlorophenylsulfonyl)-3-oxo-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 0.550nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344117(CHEMBL1777975 | N-((R)-6-((cyclopentylamino)methyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344092(2-(1-(2,4-dichlorophenylsulfonyl)-3-oxopiperazin-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.640nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344108(2-((R)-3-oxo-1-(phenylsulfonyl)piperazin-2-yl)-N-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50209744((R)-3-(4-fluorophenyl)-N-((R)-7-(piperidin-1-ylmet...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344096(2-(3-oxo-1-(3-(trifluoromethyl)phenylsulfonyl)pipe...)copy SMILEScopy InChI
Affinity DataIC50: 0.940nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344113(CHEMBL1777971 | N-((R)-6-(morpholinomethyl)-1,2,3,...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344087(2-(1-(3,4-dichlorophenylsulfonyl)-3-oxopiperazin-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344118(CHEMBL1777976 | N-((R)-6-((tert-butylamino)methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.28nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344114(CHEMBL1777972 | N-((R)-6-((4-methylpiperazin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.46nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344095(2-(3-oxo-1-(4-(trifluoromethyl)phenylsulfonyl)pipe...)copy SMILEScopy InChI
Affinity DataIC50: 1.76nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344107(2-(5-oxo-1-tosylpiperazin-2-yl)-N-((R)-6-(piperidi...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344121(CHEMBL1777979 | N-((R)-6-((neopentylamino)methyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344097(2-(1-(4-methyl-3-(trifluoromethyl)phenylsulfonyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344112(CHEMBL1777970 | N-((R)-6-((3,3-dimethylpiperidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344099(2-(1-(5-chlorobenzo[b]thiophen-2-ylsulfonyl)-3-oxo...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344102(2-((S)-3-oxo-1-tosylpiperazin-2-yl)-N-((R)-6-(pipe...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344116(CHEMBL1777974 | N-((R)-6-((cyclopropylamino)methyl...)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50182221(CHEMBL381366 | N-((R)-6-((tert-butylamino)methyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344105(2-((R)-4-methyl-3-oxo-1-tosylpiperazin-2-yl)-N-((R...)copy SMILEScopy InChI
Affinity DataIC50: 98.6nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344104(2-(5,5-dimethyl-3-oxo-1-tosylpiperazin-2-yl)-N-((R...)copy SMILEScopy InChI
Affinity DataIC50: 136nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344115(CHEMBL1777973 | N-((R)-6-(aminomethyl)-1,2,3,4-tet...)copy SMILEScopy InChI
Affinity DataIC50: 238nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344101(2-((R)-3-oxo-1-tosylpiperazin-2-yl)-N-((S)-6-(pipe...)copy SMILEScopy InChI
Affinity DataIC50: 248nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344088(2-(1-(methylsulfonyl)-3-oxopiperazin-2-yl)-N-((R)-...)copy SMILEScopy InChI
Affinity DataIC50: 475nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344103(2-((S)-3-oxo-1-tosylpiperazin-2-yl)-N-((S)-6-(pipe...)copy SMILEScopy InChI
Affinity DataIC50: 1.17E+3nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344121(CHEMBL1777979 | N-((R)-6-((neopentylamino)methyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of CYP3A4 preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344100(2-((2R)-1-((4-methylphenyl)sulfonyl)-3-oxo-2-piper...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344100(2-((2R)-1-((4-methylphenyl)sulfonyl)-3-oxo-2-piper...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344118(CHEMBL1777976 | N-((R)-6-((tert-butylamino)methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344118(CHEMBL1777976 | N-((R)-6-((tert-butylamino)methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50344121(CHEMBL1777979 | N-((R)-6-((neopentylamino)methyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79R6PubMed
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