Compile Data Set for Download or QSAR

Found 81 hits of Enzyme Inhibition Constant Data   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396257(CHEMBL2172327)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396260(CHEMBL2172324)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396258(CHEMBL2172326)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of ALK enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396257(CHEMBL2172327)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396262(CHEMBL2172322)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396261(CHEMBL2172323)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396251(CHEMBL2172337)copy SMILEScopy InChI
Affinity DataIC50: 109nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396247(CHEMBL2172336)copy SMILEScopy InChI
Affinity DataIC50: 144nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396255(CHEMBL2172329)copy SMILEScopy InChI
Affinity DataIC50: 147nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetInsulin receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)copy SMILEScopy InChI
Affinity DataIC50: 231nMAssay Description:Inhibition of INSR expressed in CHO cells assessed as inhibition of receptor phosphorylation pre-incubated before insulin stimulation by Meso-Scale D...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396246(CHEMBL2172305)copy SMILEScopy InChI
Affinity DataIC50: 345nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetInsulin receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)copy SMILEScopy InChI
Affinity DataIC50: 536nMAssay Description:Inhibition of INSR expressed in CHO cells assessed as inhibition of receptor phosphorylation pre-incubated before insulin stimulation by Meso-Scale D...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396258(CHEMBL2172326)copy SMILEScopy InChI
Affinity DataIC50: 562nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396260(CHEMBL2172324)copy SMILEScopy InChI
Affinity DataIC50: 5.12E+3nMAssay Description:Inhibition of c-Met enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396262(CHEMBL2172322)copy SMILEScopy InChI
Affinity DataIC50: 5.92E+3nMAssay Description:Inhibition of c-Met enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetLeukocyte tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)copy SMILEScopy InChI
Affinity DataKd:  8.20nMAssay Description:Binding affinity to human LTK by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)copy SMILEScopy InChI
Affinity DataKd:  72nMAssay Description:Binding affinity to human MER by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)copy SMILEScopy InChI
Affinity DataKd:  28nMAssay Description:Binding affinity to human LCK by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetLeukocyte tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)copy SMILEScopy InChI
Affinity DataKd:  2.5nMAssay Description:Binding affinity to human LTK by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)copy SMILEScopy InChI
Affinity DataKd:  1.60E+3nMAssay Description:Binding affinity to human AXL by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)copy SMILEScopy InChI
Affinity DataKd:  5.60nMAssay Description:Binding affinity to human IRAK1 by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)copy SMILEScopy InChI
Affinity DataKd:  11nMAssay Description:Binding affinity to human MAP4K2 by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)copy SMILEScopy InChI
Affinity DataKd:  25nMAssay Description:Binding affinity to human MAP4K2 by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)copy SMILEScopy InChI
Affinity DataKd:  0.360nMAssay Description:Binding affinity to human ALK by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)copy SMILEScopy InChI
Affinity DataKd:  0.240nMAssay Description:Binding affinity to human ALK by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)copy SMILEScopy InChI
Affinity DataKd:  18nMAssay Description:Binding affinity to human MER by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)copy SMILEScopy InChI
Affinity DataKd:  42nMAssay Description:Binding affinity to human FLT3 by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetInsulin receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)copy SMILEScopy InChI
Affinity DataKd:  72nMAssay Description:Binding affinity to human INSR by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)copy SMILEScopy InChI
Affinity DataKd:  110nMAssay Description:Binding affinity to human LCK by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)copy SMILEScopy InChI
Affinity DataKd:  5.70nMAssay Description:Binding affinity to human IRAK1 by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)copy SMILEScopy InChI
Affinity DataKd:  29nMAssay Description:Binding affinity to human AXL by Ambit titration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M046KTPubMed
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