Found 252 hits of Enzyme Inhibition Constant Data
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Phenex Pharmaceuticals AG
Curated by ChEMBL
Phenex Pharmaceuticals AG
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Displacement of [125I]+/-DOI from human recombinant 5-HT2B receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORbeta LBD (201 to 452 residues) expressed in HEK293T cells assessed as reduction in ROR mediated t...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Phenex Pharmaceuticals AG
Curated by ChEMBL
Phenex Pharmaceuticals AG
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Displacement of [3H]nisoxetine from recombinant human norepinephrine transporter after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Phenex Pharmaceuticals AG
Curated by ChEMBL
Phenex Pharmaceuticals AG
Curated by ChEMBL
Affinity DataIC50: 4.90nMAssay Description:Displacement of [3H]nisoxetine from recombinant human dopamine transporter after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Phenex Pharmaceuticals AG
Curated by ChEMBL
Phenex Pharmaceuticals AG
Curated by ChEMBL
Affinity DataIC50: 4.90nMAssay Description:Displacement of [3H]BRL 43694 from human recombinant 5-HT3 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.40nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]DADLE from human recombinant delta opioid receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:Displacement of [3H]SR 142801 from human recombinant NK3 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8.70nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 8.90nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 9.20nMAssay Description:Displacement of [3H]-CGS 21680 from human recombinant adenosine A2A receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Binding affinity to recombinant human RORbeta LBD (201 to 452 residues) expressed in Escherichia coli BL21 (DE3) GOLD by 1,8-ANS dye-based thermofluo...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Phenex Pharmaceuticals AG
Curated by ChEMBL
Phenex Pharmaceuticals AG
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Displacement of [125I]-CYP from rat brain 5-HT1B receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORbeta LBD (201 to 452 residues) expressed in HEK293T cells assessed as reduction in ROR mediated t...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Phenex Pharmaceuticals AG
Curated by ChEMBL
Phenex Pharmaceuticals AG
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Displacement of [125I]pirenzepine from human recombinant M1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Phenex Pharmaceuticals AG
Curated by ChEMBL
Phenex Pharmaceuticals AG
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Displacement of [3H]-RX 821002 from rat alpha2 adrenoceptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Phenex Pharmaceuticals AG
Curated by ChEMBL
Phenex Pharmaceuticals AG
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Displacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Binding affinity to recombinant human RORbeta LBD (201 to 452 residues) expressed in Escherichia coli BL21 (DE3) GOLD by 1,8-ANS dye-based thermofluo...More data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORbeta LBD (201 to 452 residues) expressed in HEK293T cells assessed as reduction in ROR mediated t...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Phenex Pharmaceuticals AG
Curated by ChEMBL
Phenex Pharmaceuticals AG
Curated by ChEMBL
Affinity DataIC50: 106nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT5a receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 115nMAssay Description:Binding affinity to recombinant human RORbeta LBD (201 to 452 residues) expressed in Escherichia coli BL21 (DE3) GOLD by 1,8-ANS dye-based thermofluo...More data for this Ligand-Target Pair
Affinity DataIC50: 119nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORbeta LBD (201 to 452 residues) expressed in HEK293T cells assessed as reduction in ROR mediated t...More data for this Ligand-Target Pair
Affinity DataIC50: 142nMAssay Description:Displacement of [125I]APT from human recombinant histamine H2 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 154nMAssay Description:Binding affinity to recombinant human RORbeta LBD (201 to 452 residues) expressed in Escherichia coli BL21 (DE3) GOLD by 1,8-ANS dye-based thermofluo...More data for this Ligand-Target Pair
