Affinity Data by PubMed id=26505898

Found 1 hit of Enzyme Inhibition Constant Data

ALK tyrosine kinase receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL

BDBM106870(US8592455, 70)copy SMILEScopy InChI

IC50: 1.00E+4nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair

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Details Article
BindingDB Entry DOI: 10.7270/Q2H41VGNPubMed

Displayed 1 to 50 (of 123 total ) | Next | Last >>* indicates data uncertainty>20%

Targets 74 ▿
- Serine/threonine-protein kinase pim-3 17
- Serine/threonine-protein kinase pim-1 17
- Serine/threonine-protein kinase pim-2 17
- Fibroblast growth factor receptor 3 2
- Receptor tyrosine-protein kinase erbB-4 1
- Tyrosine-protein kinase JAK1 1
- Receptor tyrosine-protein kinase erbB-2 1
- Mast/stem cell growth factor receptor Kit 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- ALK tyrosine kinase receptor 1
- Hepatocyte growth factor receptor 1
- Non-receptor tyrosine-protein kinase TYK2 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- Mitogen-activated protein kinase 14 1
- Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 1
- Glycogen synthase kinase-3 beta 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Interleukin-1 receptor-associated kinase 4 1
- Calcium/calmodulin-dependent protein kinase type II subunit beta 1
- Macrophage-stimulating protein receptor 1
- Tyrosine-protein kinase ABL1 1
- Protein kinase C theta type 1
- MAP kinase-interacting serine/threonine-protein kinase 2 1
- MAP kinase-interacting serine/threonine-protein kinase 1 1
- Serine/threonine-protein kinase PAK 2 1
- RAC-alpha serine/threonine-protein kinase 1
- Tyrosine-protein kinase JAK3 1
- Tyrosine-protein kinase JAK2 1
- Proto-oncogene tyrosine-protein kinase receptor Ret 1
- Rho-associated protein kinase 2 1
- Tyrosine-protein kinase ZAP-70 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Proto-oncogene tyrosine-protein kinase Src 1
- 3-phosphoinositide-dependent protein kinase 1 1
- Mitogen-activated protein kinase 1 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- Tyrosine-protein kinase Lck 1
- Cyclin-A1/Cyclin-dependent kinase 2 1
- Tyrosine-protein kinase BTK 1
- Ephrin type-A receptor 4 1
- Serine/threonine-protein kinase mTOR 1
- Mitogen-activated protein kinase 9 1
- Insulin-like growth factor 1 receptor 1
- Serine/threonine-protein kinase N2 1
- Potassium voltage-gated channel subfamily H member 2 1
- Epidermal growth factor receptor 1
- Serine/threonine-protein kinase N1 1
- Tyrosine-protein kinase SYK 1
- COUP transcription factor 1 1
- Fibroblast growth factor receptor 4 1
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 1
- Insulin receptor 1
- Vascular endothelial growth factor receptor 2 1
- Fibroblast growth factor receptor 1 1
- Tyrosine-protein kinase HCK 1
- Aurora kinase A 1
- Fibroblast growth factor receptor 2 1
- Serine/threonine-protein kinase PLK1 1
- Phosphatidylinositol 3-kinase catalytic subunit type 3 1
- Mitogen-activated protein kinase 12 1
- Mitogen-activated protein kinase 10 1
- Casein kinase I isoform alpha 1
- Tyrosine-protein kinase Fyn 1
- Tyrosine-protein kinase CSK 1
- Tyrosine-protein kinase Lyn 1
- Protein kinase C alpha type 1
- Focal adhesion kinase 1 1
- Platelet-derived growth factor receptor alpha 1
- Ephrin type-B receptor 4 1
- Tyrosine-protein kinase Yes 1
- MAP kinase-activated protein kinase 2 1
- Serine/threonine-protein kinase WNK1 1
- MAP kinase-activated protein kinase 5 1
- Phosphatidylinositol 4-kinase beta 1
Publications 1 ▿
- J Med Chem 58: 8373-86 (2015) 123
Institutions 1 ▿
- [Novartis Institutes for Biomedical Research] 123
Affinity: 0.0060 to 1.2E+4 nM▿
- Ki 51
- IC50 72
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 3