Affinity Data by PubMed id=30532965

Found 1 hit of Enzyme Inhibition Constant Data

Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL

BDBM50521215(CHEMBL4435246)copy SMILEScopy InChI

IC50: 5.01E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells after 75 mins by fluorescence polarization assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article
BindingDB Entry DOI: 10.7270/Q2Z60SFQPubMed

Displayed 1 to 50 (of 81 total ) | Next | Last >>* indicates data uncertainty>20%

Targets 21 ▿
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 16
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 16
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 16
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 16
- Tyrosine-protein kinase Lck 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Tyrosine-protein kinase BTK 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Mitogen-activated protein kinase kinase kinase 5 1
- Mitogen-activated protein kinase 10 1
- Tyrosine-protein kinase ITK/TSK 1
- Potassium voltage-gated channel subfamily H member 2 1
- Epidermal growth factor receptor 1
- Tyrosine-protein kinase SYK 1
- Tyrosine-protein kinase JAK3 1
- Tyrosine-protein kinase JAK2 1
- Leucine-rich repeat serine/threonine-protein kinase 2 1
- Rho-associated protein kinase 1 1
- Mitogen-activated protein kinase 14 1
- Aurora kinase B 1
- Glycogen synthase kinase-3 beta 1
Publications 1 ▿
- J Med Chem 61: 11061-11073 (2018) 81
Institutions 1 ▿
- [GlaxoSmithKline R&D] 81
Affinity: 0.079 to 1.6E+5 nM▿
- Ki 2
- IC50 79
- Affinity ≤ nM
Xtal structures: 6
Docked structures: 0
Catalog Cmpds: 3