Compile Data Set for Download or QSAR

Found 85 hits of Enzyme Inhibition Constant Data   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134444(CHEMBL3747085)copy SMILEScopy InChI
Affinity DataEC50:  186nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134446(CHEMBL3747597)copy SMILEScopy InChI
Affinity DataEC50:  759nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134455(CHEMBL3747522)copy SMILEScopy InChI
Affinity DataEC50:  490nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134440(CHEMBL3745940)copy SMILEScopy InChI
Affinity DataEC50:  760nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134463(CHEMBL3747012)copy SMILEScopy InChI
Affinity DataEC50:  690nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134465(CHEMBL3746325)copy SMILEScopy InChI
Affinity DataEC50:  91nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134443(CHEMBL3746457)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in HEK293 cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134479(CHEMBL3745901)copy SMILEScopy InChI
Affinity DataEC50:  158nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134480(CHEMBL3746731)copy SMILEScopy InChI
Affinity DataEC50:  126nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134438(CHEMBL3747073)copy SMILEScopy InChI
Affinity DataEC50:  71nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134440(CHEMBL3745940)copy SMILEScopy InChI
Affinity DataEC50:  759nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134443(CHEMBL3746457)copy SMILEScopy InChI
Affinity DataEC50:  126nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134445(CHEMBL3746298)copy SMILEScopy InChI
Affinity DataEC50:  617nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134474(CHEMBL3746294)copy SMILEScopy InChI
Affinity DataEC50:  1.23E+3nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134476(CHEMBL3746299)copy SMILEScopy InChI
Affinity DataEC50: <3.02E+4nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134480(CHEMBL3746731)copy SMILEScopy InChI
Affinity DataEC50:  130nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134437(CHEMBL3746591)copy SMILEScopy InChI
Affinity DataEC50:  87nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134438(CHEMBL3747073)copy SMILEScopy InChI
Affinity DataEC50:  71nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134449(CHEMBL3745812)copy SMILEScopy InChI
Affinity DataEC50:  100nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134457(CHEMBL3746779)copy SMILEScopy InChI
Affinity DataEC50:  3.98E+3nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu1 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134443(CHEMBL3746457)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu6 receptor expressed in CHO cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134441(CHEMBL3746240)copy SMILEScopy InChI
Affinity DataEC50:  2.09E+3nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134442(CHEMBL3747717)copy SMILEScopy InChI
Affinity DataEC50:  2.09E+3nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134457(CHEMBL3746779)copy SMILEScopy InChI
Affinity DataEC50:  3.98E+3nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134453(CHEMBL3746604)copy SMILEScopy InChI
Affinity DataEC50:  300nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134468(CHEMBL3747072)copy SMILEScopy InChI
Affinity DataEC50:  7.76E+3nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134476(CHEMBL3746299)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134443(CHEMBL3746457)copy SMILEScopy InChI
Affinity DataEC50:  6.76E+3nMAssay Description:Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134443(CHEMBL3746457)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in L929sA cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134463(CHEMBL3747012)copy SMILEScopy InChI
Affinity DataEC50:  692nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)copy SMILEScopy InChI
Affinity DataEC50:  158nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134468(CHEMBL3747072)copy SMILEScopy InChI
Affinity DataEC50:  7.76E+3nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134473(CHEMBL3747078)copy SMILEScopy InChI
Affinity DataEC50:  2.82E+3nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134439(CHEMBL3747662)copy SMILEScopy InChI
Affinity DataEC50:  110nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134441(CHEMBL3746240)copy SMILEScopy InChI
Affinity DataEC50:  2.09E+3nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134442(CHEMBL3747717)copy SMILEScopy InChI
Affinity DataEC50:  2.09E+3nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134444(CHEMBL3747085)copy SMILEScopy InChI
Affinity DataEC50:  190nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134455(CHEMBL3747522)copy SMILEScopy InChI
Affinity DataEC50:  490nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)copy SMILEScopy InChI
Affinity DataEC50:  160nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134467(CHEMBL3747260)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)copy SMILEScopy InChI
Affinity DataEC50:  3.39E+3nMAssay Description:Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134448(CHEMBL3747118)copy SMILEScopy InChI
Affinity DataEC50:  100nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134467(CHEMBL3747260)copy SMILEScopy InChI
Affinity DataEC50: <3.02E+4nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134469(CHEMBL3746344)copy SMILEScopy InChI
Affinity DataEC50:  540nMAssay Description:Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134443(CHEMBL3746457)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50134443(CHEMBL3746457)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1NGSPubMed
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