Compile Data Set for Download or QSAR

Found 31 hits of Enzyme Inhibition Constant Data   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50174298(3-(4-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)bicy...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50202102(CHEMBL375156 | N-(5-Hydroxy-adamantan-2-yl)-2-[4-(...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273862(CHEMBL462305 | N-(5-Hydroxy-adamantan-2-yl)-2-m-to...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273859(2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxyc...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273861(CHEMBL462304 | N-(3-((4aS,8aR)-decahydroquinoline-...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273455(2-[(S)-1-(2-Chlorophenyl)ethylamino]-5-(2-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273858(2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxyc...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273458((5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273456((S)-5-(2-Hydroxypropan-2-yl)-5-methyl-2-{1-[2-(tri...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
TargetHydroxysteroid 11-beta dehydrogenase 1(Canis familiaris)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273458((5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibition of dog 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273857(2-((S)-1-(4-fluorophenyl)ethylamino)-5-(2-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273822(5-(4-Fluorophenyl)-2-[(S)-1-(4-fluorophenyl)ethyla...)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273454(2-[(S)-1-(2-Fluorophenyl)ethylamino]-5-(2-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273403(2-[(S)-1-(4-Chlorophenyl)ethylamino]-5-(3-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273398(4-{2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methyl-4...)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273825(1-(4-{2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methy...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273855(2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-[4-(hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273827(2-{(S)-[1-(4-fluorophenyl)ethyl]amino}-5-[4-(2-hyd...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273458((5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273405(2-[(S)-1-(3-Fluorophenyl)ethylamino]-5-(2-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50167718(2-(phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)et...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273457((R)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydr...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273856(2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydroxy-...)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273458((5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-...)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:Inhibition of rat 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273824(3-(4-{2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methy...)copy SMILEScopy InChI
Affinity DataIC50: 680nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273857(2-((S)-1-(4-fluorophenyl)ethylamino)-5-(2-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cells using [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273455(2-[(S)-1-(2-Chlorophenyl)ethylamino]-5-(2-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cells using [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273859(2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxyc...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cells using [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273454(2-[(S)-1-(2-Fluorophenyl)ethylamino]-5-(2-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cells using [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273456((S)-5-(2-Hydroxypropan-2-yl)-5-methyl-2-{1-[2-(tri...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cells using [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50273858(2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxyc...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cells using [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GN7PubMed
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