Found 34 hits of Enzyme Inhibition Constant Data
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as NADPH consumption using alpha-ketoglutarate as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as NADPH consumption using alpha-ketoglutarate as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibitory concentration against binding of rat Gonadotropin-releasing hormone receptor using [125-I]buserelinMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibitory concentration against glyceraldehyde-3-phosphate dehydrogenase was determined as log 1/IC50More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 102nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 116nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 145nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 258nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 316nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 339nMAssay Description:Blockage of Nicotinic acetylcholine receptor alpha7 noncompetitively in hippocampal primary culturesMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) expressed in human HCT116 cells assessed as reduction in 2-HG levelMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 6.14E+3nMAssay Description:Inhibition of wild-type IDH1 (unknown origin) assessed as NADPH production using isocitrate as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IDH2 R172K mutant (unknown origin) expressed in human HCT116 cells assessed as reduction in 2-HG levelMore data for this Ligand-Target Pair