Compile Data Set for Download or QSAR

Found 6 hits of Enzyme Inhibition Constant Data   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22418(Cocaine | Cocaine (-) | methyl (1R,2R,3S,5S)-3-(be...)copy SMILEScopy InChI
Affinity DataKi:  272nM EC50:  267nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMedDrugBank
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22418(Cocaine | Cocaine (-) | methyl (1R,2R,3S,5S)-3-(be...)copy SMILEScopy InChI
Affinity DataKi:  601nM EC50:  318nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22418(Cocaine | Cocaine (-) | methyl (1R,2R,3S,5S)-3-(be...)copy SMILEScopy InChI
Affinity DataKi:  830nM EC50:  385nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMedDrugBank
TargetTransporter(Rattus norvegicus (rat))
Research Triangle Institute

LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)copy SMILEScopy InChI
Affinity DataKi:  920nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)copy SMILEScopy InChI
Affinity DataKi:  1.90E+3nM ΔG°:  -32.7kJ/molepH: 7.4 T: 2°CAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Triangle Institute

LigandPNGBDBM22396((1R,2S,3S,5S)-3-(4-chlorophenyl)-2-[5-(4-fluorophe...)copy SMILEScopy InChI
Affinity DataIC50: 23nMpH: 7.4 T: 2°CAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
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