Found 55 hits of Enzyme Inhibition Constant Data
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataKi: 5.5nMAssay Description:Inhibition of human ALDH1A1 using propionaldehyde as substrate and varied concentration of NAD+ as cofactor preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataKi: 7.20nMAssay Description:Inhibition of human ALDH1A1 using propionaldehyde as substrate and varied concentration of NAD+ as cofactor preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataKi: 23nMAssay Description:Inhibition of human ALDH1A1 using NAD+ as cofactor and varied concentration of propionaldehyde as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Inhibition of human ALDH1A1 using NAD+ as cofactor and varied concentration of propionaldehyde as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 30 uM after...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human ALDH1A1 using NAD+/propionaldehyde as substrate/cofactor preincubated for 15 mins followed by substrate/cofactor addition measure...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human ALDH1A1 using NAD+/propionaldehyde as substrate/cofactor preincubated for 15 mins followed by substrate/cofactor addition measure...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human ALDH1A1 using NAD+/propionaldehyde as substrate/cofactor preincubated for 15 mins followed by substrate/cofactor addition measure...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 9.20nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 20 uM after...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human ALDH1A1 using NAD+/propionaldehyde as substrate/cofactor preincubated for 15 mins followed by substrate/cofactor addition measure...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of human ALDH1A1 using NAD+/propionaldehyde as substrate/cofactor preincubated for 15 mins followed by substrate/cofactor addition measure...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human ALDH1A1 using all-trans-retinal as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by fluo...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 10 uM after...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of ALDH1A1 in human MIAPaCa2 cells after 30 mins by aldefluor assayMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 30 uM after...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of human ALDH1A1 using NAD+/propionaldehyde as substrate/cofactor preincubated for 15 mins followed by substrate/cofactor addition measure...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of human ALDH1A1 using all-trans-retinal as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by fluo...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human ALDH1A1 using NAD+/propionaldehyde as substrate/cofactor preincubated for 15 mins followed by substrate/cofactor addition measure...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of ALDH1A1 in human MIAPaCa2 cells after 30 mins by aldefluor assayMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of ALDH1A1 in human MIAPaCa2 cells after 30 mins by aldefluor assayMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 102nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 20 uM after...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 119nMAssay Description:Inhibition of human ALDH1A1 using NAD+/propionaldehyde as substrate/cofactor preincubated for 15 mins followed by substrate/cofactor addition measure...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 226nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 3 uM after ...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 390nMAssay Description:Inhibition of full length recombinant human ALDH1A1 expressed in Escherichia coli BL21 cells using acetyladehyde as substrate preincubated for 5 mins...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 411nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 10 uM after...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 848nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 1 uM after ...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 870nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 3 uM after ...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 924nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 1 uM after ...More data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of ALDH1A1 in human MIAPaCa2 cells after 30 mins by aldefluor assayMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 3.43E+3nMAssay Description:Inhibition of ALDH1A1 in human MIAPaCa2 cells after 30 mins by aldefluor assayMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 4.87E+3nMAssay Description:Inhibition of ALDH1A1 in human MIAPaCa2 cells after 30 mins by aldefluor assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 5.46E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 6.79E+3nMAssay Description:Inhibition of ALDH1A1 in human MIAPaCa2 cells after 30 mins by aldefluor assayMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 6.89E+3nMAssay Description:Inhibition of human ALDH1A1 using NAD+/propionaldehyde as substrate/cofactor preincubated for 15 mins followed by substrate/cofactor addition measure...More data for this Ligand-Target Pair
3D Structure (crystal)TargetCytochrome P450 2C9(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4 using midazolam as substrateMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4 using midazolam as substrateMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of ALDH1A1 in human MIAPaCa2 cells after 30 mins by aldefluor assayMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataEC50: 2.00E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature after 1 hr by CETSAMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataEC50: 7.79E+3nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of 100 nM paclitaxel-mediated cytotoxicity after 4 days by CellTiter-Glo assayMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataEC50: 3.40E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature at 70 degC after 1 hr by CETSAMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataEC50: 5.59E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature at 70 degC after 1 hr by CETSAMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataEC50: 3.04E+3nMAssay Description:Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of 100 nM paclitaxel-mediated cytotoxicity after 4 days by CellTiter-Glo assayMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataEC50: 2.00E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature after 1 hr by CETSAMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature at 70 degC after 1 hr by CETSAMore data for this Ligand-Target Pair
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataEC50: 3.15E+3nMAssay Description:Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature at 70 degC after 1 hr by CETSAMore data for this Ligand-Target Pair
