Compile Data Set for Download or QSAR

Found 13 hits of Enzyme Inhibition Constant Data   

TargetAurora kinase A(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)copy SMILEScopy InChI
Affinity DataKi:  0.600nMAssay Description:Inhibition of recombinant N-terminal His6-tagged Aurora A (62 to 344 residues) (unknown origin) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98WRPubMed
TargetAurora kinase C(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)copy SMILEScopy InChI
Affinity DataKi:  4.60nMAssay Description:Inhibition of recombinant N-terminal His6-tagged Aurora C (1 to 309 residues) (unknown origin) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98WRPubMed
TargetAurora kinase B(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)copy SMILEScopy InChI
Affinity DataKi:  18nMAssay Description:Inhibition of recombinant N-terminal His6-tagged Aurora B (1 to 403 residues) (unknown origin) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98WRPubMed
TargetAurora kinase A(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50466804(CHEMBL4289017)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant full-length His-tagged Aurora A (unknown origin) expressed in insect cells using biotinylated LRRWSLG as substrate in prese...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98WRPubMed
TargetAurora kinase A(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)copy SMILEScopy InChI
Affinity DataIC50: 0.950nMAssay Description:Inhibition of Aurora A (unknown origin) using kemptide acetate salt as substrate after 30 mins by kinase-Glo luminescence methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98WRPubMed
TargetAurora kinase A(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98WRPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50277584(CHEMBL482968 | N-(5-methyl-1H-pyrazol-3-yl)-6-(4-m...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant human FLT3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98WRPubMed
TargetAurora kinase A(Mus musculus (mouse))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant mouse Aurora A kinase expressed in Sf9 cells using Biotin-GLRRASLG as substrate in presence of [gamma33]P-ATP by FlashPlate...More data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50466804(CHEMBL4289017)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant full-length His-tagged Aurora B (unknown origin) expressed in insect cells using biotinylated LRRWSLG as substrate measured...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98WRPubMed
TargetAurora kinase A(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of Aurora A phosphorylation at Thr288 residue in human HeLa cells after 12 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98WRPubMed
TargetAurora kinase A(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50277584(CHEMBL482968 | N-(5-methyl-1H-pyrazol-3-yl)-6-(4-m...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human Aurora AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98WRPubMed
TargetAurora kinase B(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of Aurora B (unknown origin) using kemptide acetate salt as substrate after 30 mins by kinase-Glo luminescence methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98WRPubMed
TargetAurora kinase B(Homo sapiens (Human))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)copy SMILEScopy InChI
Affinity DataIC50: 148nMAssay Description:Inhibition of Aurora B phosphorylation at Thr232 residue in human HeLa cells after 12 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN98WRPubMed
* indicates data uncertainty>20%