Compile Data Set for Download or QSAR

Found 12 hits of Enzyme Inhibition Constant Data   

TargetCarbonic anhydrase 7(Homo sapiens (Human))
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:Inhibition of recombinant human carbonic anhydrase 7 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-f...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-f...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)copy SMILEScopy InChI
Affinity DataKi:  74nMAssay Description:Inhibition of recombinant human carbonic anhydrase 4 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-f...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)copy SMILEScopy InChI
Affinity DataKi:  250nMAssay Description:Inhibition of transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50279397(CHEMBL4169151 | US11311527, Cpd ID IDH889 | US1137...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM247859(US10112931, Example 466 | US9434719, 466 | US96886...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM50279397(CHEMBL4169151 | US11311527, Cpd ID IDH889 | US1137...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM247859(US10112931, Example 466 | US9434719, 466 | US96886...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Effect on human Glucocorticoid receptor (GR) in a whole cell assay to measure functional cellular GR-antagonism (GRAF)More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM247859(US10112931, Example 466 | US9434719, 466 | US96886...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM247859(US10112931, Example 466 | US9434719, 466 | US96886...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as NADPH consumption using alpha-ketoglutarate as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM247859(US10112931, Example 466 | US9434719, 466 | US96886...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin) assessed as NADPH consumption using alpha-ketoglutarate as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University

Curated by ChEMBL
LigandPNGBDBM247859(US10112931, Example 466 | US9434719, 466 | US96886...)copy SMILEScopy InChI
Affinity DataIC50: 6.14E+3nMAssay Description:Inhibition of wild-type IDH1 (unknown origin) assessed as NADPH production using isocitrate as substrate by fluorescence assayMore data for this Ligand-Target Pair
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