Affinity Data by PubMed id=26951750

Found 1 hit of Enzyme Inhibition Constant Data

Insulin-like growth factor 1 receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL

PNG

BDBM50157879(CHEMBL1614712)copy SMILEScopy InChI

IC50: 61nMAssay Description:Inhibition of IGF-1 receptor (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Details Article
BindingDB Entry DOI: 10.7270/Q21Z469MPubMed PDB

3D Structure (crystal)

Displayed 1 to 50 (of 59 total ) | Next | Last >>* indicates data uncertainty>20%

Targets 11 ▿
- Insulin-like growth factor 1 receptor 20
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 4
- Tyrosine-protein kinase Lck 4
- Ephrin type-B receptor 4 4
- Proto-oncogene tyrosine-protein kinase receptor Ret 4
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 4
- Tyrosine-protein kinase JAK1 4
- Vascular endothelial growth factor receptor 2 4
- Insulin receptor 4
- Epidermal growth factor receptor 4
- Potassium voltage-gated channel subfamily H member 2 3
Publications 1 ▿
- Bioorg Med Chem Lett 26: 2065-7 (2016) 59
Institutions 1 ▿
- [Novartis Institutes for Biomedical Research] 59
Affinity: 5 to 1.0E+4 nM▿
- IC50 59
- Affinity ≤ nM
Xtal structures: 2
Docked structures: 0
Catalog Cmpds: 1