Compile Data Set for Download or QSAR

Found 32 hits of Enzyme Inhibition Constant Data   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082406(1-(2-fluorophenoxy)-3-spiro[1,3-dihydrobenzo[e]iso...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082405(1-phenoxy-3-spiro[1,3-dihydrobenzo[e]isobenzofuran...)copy SMILEScopy InChI
Affinity DataKi:  1.10nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082413(1-(3-ethylphenoxy)-3-spiro[1,3-dihydrobenzo[e]isob...)copy SMILEScopy InChI
Affinity DataKi:  1.70nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082408(1-benzyloxy-3-spiro[1,3-dihydrobenzo[e]isobenzofur...)copy SMILEScopy InChI
Affinity DataKi:  2.20nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082410(4-fluoro-7-[2-hydroxy-3-spiro[1,3-dihydrobenzo[e]i...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082411(1-(5-fluoro-3,4-dihydro-2H-8-chromenyloxy)-3-spiro...)copy SMILEScopy InChI
Affinity DataKi:  2.80nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082407(1-(6-fluoro-3,4-dihydro-2H-8-chromenyloxy)-3-spiro...)copy SMILEScopy InChI
Affinity DataKi:  5.5nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082415(1-(2-fluorophenoxy)-3-spiro[1,3-dihydrobenzo[e]iso...)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082412(1-phenyl-3-spiro[1,3-dihydrobenzo[e]isobenzofuran-...)copy SMILEScopy InChI
Affinity DataKi:  8.30nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082412(1-phenyl-3-spiro[1,3-dihydrobenzo[e]isobenzofuran-...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)copy SMILEScopy InChI
Affinity DataKi:  24nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082414(1'-(4-phenylbutyl)spiro[1,3-dihydrobenzo[e]isobenz...)copy SMILEScopy InChI
Affinity DataKi:  28nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082410(4-fluoro-7-[2-hydroxy-3-spiro[1,3-dihydrobenzo[e]i...)copy SMILEScopy InChI
Affinity DataKi:  45nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082411(1-(5-fluoro-3,4-dihydro-2H-8-chromenyloxy)-3-spiro...)copy SMILEScopy InChI
Affinity DataKi:  49nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082405(1-phenoxy-3-spiro[1,3-dihydrobenzo[e]isobenzofuran...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082406(1-(2-fluorophenoxy)-3-spiro[1,3-dihydrobenzo[e]iso...)copy SMILEScopy InChI
Affinity DataKi:  52nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082414(1'-(4-phenylbutyl)spiro[1,3-dihydrobenzo[e]isobenz...)copy SMILEScopy InChI
Affinity DataKi:  72nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082407(1-(6-fluoro-3,4-dihydro-2H-8-chromenyloxy)-3-spiro...)copy SMILEScopy InChI
Affinity DataKi:  72nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082408(1-benzyloxy-3-spiro[1,3-dihydrobenzo[e]isobenzofur...)copy SMILEScopy InChI
Affinity DataKi:  83nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082413(1-(3-ethylphenoxy)-3-spiro[1,3-dihydrobenzo[e]isob...)copy SMILEScopy InChI
Affinity DataKi:  87nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082415(1-(2-fluorophenoxy)-3-spiro[1,3-dihydrobenzo[e]iso...)copy SMILEScopy InChI
Affinity DataKi:  120nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)copy SMILEScopy InChI
Affinity DataKi: >7.00E+3nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082413(1-(3-ethylphenoxy)-3-spiro[1,3-dihydrobenzo[e]isob...)copy SMILEScopy InChI
Affinity DataEC50:  3.30nMAssay Description:Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082411(1-(5-fluoro-3,4-dihydro-2H-8-chromenyloxy)-3-spiro...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082414(1'-(4-phenylbutyl)spiro[1,3-dihydrobenzo[e]isobenz...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082415(1-(2-fluorophenoxy)-3-spiro[1,3-dihydrobenzo[e]iso...)copy SMILEScopy InChI
Affinity DataEC50:  21nMAssay Description:Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082405(1-phenoxy-3-spiro[1,3-dihydrobenzo[e]isobenzofuran...)copy SMILEScopy InChI
Affinity DataEC50:  1.20nMAssay Description:Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082412(1-phenyl-3-spiro[1,3-dihydrobenzo[e]isobenzofuran-...)copy SMILEScopy InChI
Affinity DataEC50:  37nMAssay Description:Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082406(1-(2-fluorophenoxy)-3-spiro[1,3-dihydrobenzo[e]iso...)copy SMILEScopy InChI
Affinity DataEC50:  1.10nMAssay Description:Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)copy SMILEScopy InChI
Affinity DataEC50:  27nMAssay Description:Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082408(1-benzyloxy-3-spiro[1,3-dihydrobenzo[e]isobenzofur...)copy SMILEScopy InChI
Affinity DataEC50:  31nMAssay Description:Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082410(4-fluoro-7-[2-hydroxy-3-spiro[1,3-dihydrobenzo[e]i...)copy SMILEScopy InChI
Affinity DataEC50:  3.5nMAssay Description:Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W37WVBPubMed
* indicates data uncertainty>20%