Compile Data Set for Download or QSAR

Found 22 hits of Enzyme Inhibition Constant Data   

TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122759(2-Methyl-4-phenylethynyl-thiazole | CHEMBL63042)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:Tested for displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl) pyridine from Metabotropic glutamate receptor 5 in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Tested for displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl) pyridine from Metabotropic glutamate receptor 5 in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)copy SMILEScopy InChI
Affinity DataKi:  16nMAssay Description:Tested for displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl) pyridine from Metabotropic glutamate receptor 5 in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122762(4-Methyl-2-phenylethynyl-thiazole | CHEMBL65417)copy SMILEScopy InChI
Affinity DataKi:  32nMAssay Description:Tested for displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl) pyridine from Metabotropic glutamate receptor 5 in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122757(2-(2-Methyl-thiazol-4-ylethynyl)-pyridine | CHEMBL...)copy SMILEScopy InChI
Affinity DataKi:  48nMAssay Description:Tested for displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl) pyridine from Metabotropic glutamate receptor 5 in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122761(4-Phenylethynyl-thiazole | CHEMBL63093)copy SMILEScopy InChI
Affinity DataKi:  142nMAssay Description:Tested for displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl) pyridine from Metabotropic glutamate receptor 5 in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122760(2-Phenylethynyl-thiazole | CHEMBL65886)copy SMILEScopy InChI
Affinity DataKi:  153nMAssay Description:Tested for displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl) pyridine from Metabotropic glutamate receptor 5 in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122763(4-(2-Methyl-thiazol-4-ylethynyl)-pyridine | CHEMBL...)copy SMILEScopy InChI
Affinity DataKi:  214nMAssay Description:Tested for displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl) pyridine from Metabotropic glutamate receptor 5 in rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Tested in vitro against human recombinant Metabotropic glutamate receptor 5 stably expressed in LtK cells by [Ca2+] flux assay using glutamate as ant...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Tested in vitro against human recombinant Metabotropic glutamate receptor 5 stably expressed in LtK cells by [Ca2+] flux assay using glutamate as ant...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122759(2-Methyl-4-phenylethynyl-thiazole | CHEMBL63042)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Tested in vitro against human recombinant Metabotropic glutamate receptor 5 stably expressed in LtK cells by [Ca2+] flux assay using glutamate as ant...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122762(4-Methyl-2-phenylethynyl-thiazole | CHEMBL65417)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Tested in vitro against human recombinant Metabotropic glutamate receptor 5 stably expressed in LtK cells by [Ca2+] flux assay using glutamate as ant...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122757(2-(2-Methyl-thiazol-4-ylethynyl)-pyridine | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Tested in vitro against human recombinant Metabotropic glutamate receptor 5 stably expressed in LtK cells by [Ca2+] flux assay using glutamate as ant...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122760(2-Phenylethynyl-thiazole | CHEMBL65886)copy SMILEScopy InChI
Affinity DataIC50: 81nMAssay Description:Tested in vitro against human recombinant Metabotropic glutamate receptor 5 stably expressed in LtK cells by [Ca2+] flux assay using glutamate as ant...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122761(4-Phenylethynyl-thiazole | CHEMBL63093)copy SMILEScopy InChI
Affinity DataIC50: 97nMAssay Description:Tested in vitro against human recombinant Metabotropic glutamate receptor 5 stably expressed in LtK cells by [Ca2+] flux assay using glutamate as ant...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122763(4-(2-Methyl-thiazol-4-ylethynyl)-pyridine | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 122nMAssay Description:Tested in vitro against human recombinant Metabotropic glutamate receptor 5 stably expressed in LtK cells by [Ca2+] flux assay using glutamate as ant...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetAmine oxidase [flavin-containing] A(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Tested for in vitro antagonistic activity against Monoamine oxidaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+4nMAssay Description:Tested for in vitro antagonistic activity against human N-methyl-D-aspartate glutamate receptor 2BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetAmine oxidase [flavin-containing] A(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Tested for in vitro antagonistic activity against Monoamine oxidase AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Tested for in vitro antagonistic activity against Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Tested for in vitro antagonistic activity against Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+5nMAssay Description:Tested for in vitro antagonistic activity against recombinat human N-methyl-D-aspartate glutamate receptor 2BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P5ZT7PubMed
* indicates data uncertainty>20%