Compile Data Set for Download or QSAR

Found 16 hits of Enzyme Inhibition Constant Data   

TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Torpedo californica)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of currents when compound wascoapplied with acetylcholine to recombinant Torpedo nAcChoR (from 6 oocytes)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0FVZPubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(MOUSE)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125934(3-(1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant embryonic mouse muscle Nicotinic Acetylcholine Receptor (3 oocytes)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0FVZPubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Torpedo californica)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)copy SMILEScopy InChI
Affinity DataIC50: 4.10E+4nMAssay Description:In vitro inhibition of 5-[125I]-A-85,380 binding to alpha2 beta4 nicotinic acetylcholine receptor (nAChR) in rat brainMore data for this Ligand-Target Pair
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(MOUSE)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant embryonic mouse muscle Nicotinic Acetylcholine Receptor (3 oocytes)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0FVZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125939(3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)copy SMILEScopy InChI
Affinity DataIC50: 6.63E+4nMAssay Description:In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0FVZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)copy SMILEScopy InChI
Affinity DataIC50: 1.04E+5nMAssay Description:In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0FVZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125937(3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)copy SMILEScopy InChI
Affinity DataIC50: 2.95E+5nMAssay Description:In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0FVZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)copy SMILEScopy InChI
Affinity DataIC50: 5.77E+5nMAssay Description:Inhibition of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125937(3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)copy SMILEScopy InChI
Affinity DataEC50:  4.70E+4nMAssay Description:Enhancement of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0FVZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)copy SMILEScopy InChI
Affinity DataEC50:  6.40E+4nMAssay Description:Enhancement of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)copy SMILEScopy InChI
Affinity DataEC50:  1.20E+3nMAssay Description:Ability to enhance currents from alpha-1-beta-2-gamma-2L-subunit of GABA receptor elicited by low concentrations of GABAMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)copy SMILEScopy InChI
Affinity DataEC50:  3.70E+4nMAssay Description:Direct activation of Gamma-aminobutyric acid A receptor in the absence of GABAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0FVZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)copy SMILEScopy InChI
Affinity DataEC50:  1.20E+3nMAssay Description:In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0FVZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)copy SMILEScopy InChI
Affinity DataEC50:  2.00E+3nMAssay Description:Direct activation of Gamma-aminobutyric acid A receptor in the absence of GABAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0FVZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125939(3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)copy SMILEScopy InChI
Affinity DataEC50:  2.00E+4nMAssay Description:Enhancement of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0FVZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)copy SMILEScopy InChI
Affinity DataEC50:  2.50E+3nMAssay Description:In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brainMore data for this Ligand-Target Pair
* indicates data uncertainty>20%