Compile Data Set for Download or QSAR

Found 29 hits of Enzyme Inhibition Constant Data   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14805(3-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14805(3-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14803(2-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14804(1-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...)copy SMILEScopy InChI
Affinity DataIC50: 3.70E+3nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14803(2-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14804(1-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...)copy SMILEScopy InChI
Affinity DataIC50: 5.50E+3nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14801(2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 6.10E+3nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14799(2-[5,6-Bis-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 1.54E+4nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14800(2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-et...)copy SMILEScopy InChI
Affinity DataIC50: 2.09E+4nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14802((5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-acet...)copy SMILEScopy InChI
Affinity DataIC50: 2.29E+4nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14799(2-[5,6-Bis-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 2.94E+4nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14810(2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14813(2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}amino)pr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14807(3-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-pr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14812((5,6-Diphenyl-furo[2,3-d]pyrimidin-4-yl)-(2-methox...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14811(N-(2-aminoethyl)-5,6-diphenylfuro[2,3-d]pyrimidin-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14808(Benzyl-(5,6-diphenyl-furo[2,3-d]pyrimidin-4-yl)-am...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14809(N-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-yl)-benzami...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14806(5,6-Diphenyl-furo[2,3-d]pyrimidin-4 -ylamine | 5,6...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP....More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14801(2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.11E+5nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14800(2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-et...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14800(2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-et...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14799(2-[5,6-Bis-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14804(1-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14803(2-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14802((5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-acet...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14801(2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}(methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14802((5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-acet...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM14805(3-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7FXSPubMed
* indicates data uncertainty>20%