Compile Data Set for Download or QSAR

Found 11 hits of Enzyme Inhibition Constant Data   

TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211499((1S,3R)-N-[3,5-bis(trifluoromethyl)benzyl]-1-methy...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HCFPubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211497((1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HCFPubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211497((1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced calcium flux in human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HCFPubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211502((1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)copy SMILEScopy InChI
Affinity DataIC50: 7.5nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HCFPubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211503(CHEMBL226376 | cis-(1S,3R)-N-(3,5-bis(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HCFPubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211500((1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HCFPubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211497((1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Antagonist activity against human CCR2 receptor in human monocytes assessed as inhibition of chemotaxisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HCFPubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211498(CHEMBL388308 | N-(3,5-bis(trifluoromethyl)benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 65nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HCFPubMed
TargetC-C chemokine receptor type 2(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211499((1S,3R)-N-[3,5-bis(trifluoromethyl)benzyl]-1-methy...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Displacement of [125]hMCP1 from mouse CCR2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HCFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211499((1S,3R)-N-[3,5-bis(trifluoromethyl)benzyl]-1-methy...)copy SMILEScopy InChI
Affinity DataIC50: 630nMAssay Description:Displacement of MIP1alpha from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HCFPubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50211501((1R,4R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125]hMCP1 from human CCR2 receptor expressed in human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HCFPubMed
* indicates data uncertainty>20%