Compile Data Set for Download or QSAR

Found 23 hits of Enzyme Inhibition Constant Data   

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18428(Aminoquinoline compound, 1 | N-[4-methyl-2-(morpho...)copy SMILEScopy InChI
Affinity DataKi:  21nM ΔG°:  -43.2kJ/mole IC50: 31nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18438(4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2...)copy SMILEScopy InChI
Affinity DataKi:  52nM ΔG°:  -41.0kJ/mole IC50: 103nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18431(Aminoquinoline compound, 16 | N-[4-methyl-2-(morph...)copy SMILEScopy InChI
Affinity DataKi:  55nM ΔG°:  -40.9kJ/mole IC50: 133nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18430(4-methyl-N-[4-methyl-2-(morpholin-4-yl)quinolin-6-...)copy SMILEScopy InChI
Affinity DataKi:  56nM ΔG°:  -40.8kJ/mole IC50: 63nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18439(N-(5-methyl-1,2-oxazol-3-yl)-4-[(4-methylbenzene)s...)copy SMILEScopy InChI
Affinity DataKi:  102nM ΔG°:  -39.4kJ/mole IC50: 168nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18433(4-methyl-N-[4-methyl-2-(4-methylpiperidin-1-yl)qui...)copy SMILEScopy InChI
Affinity DataKi:  120nM ΔG°:  -39.0kJ/mole IC50: 268nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18432(Aminoquinoline compound, 17 | N-[4-methyl-2-(morph...)copy SMILEScopy InChI
Affinity DataKi:  121nM ΔG°:  -39.0kJ/mole IC50: 183nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18434(4-methyl-N-[4-methyl-2-(piperidin-1-yl)quinolin-6-...)copy SMILEScopy InChI
Affinity DataKi:  184nM ΔG°:  -37.9kJ/mole IC50: 452nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18447(2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrroli...)copy SMILEScopy InChI
Affinity DataKi:  320nM ΔG°:  -36.6kJ/mole IC50: 430nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18435(Aminoquinoline compound, 20 | N-[2-(diethylamino)-...)copy SMILEScopy InChI
Affinity DataKi:  514nM ΔG°:  -35.4kJ/mole IC50: 1.06E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18443(4-[(4-chlorobenzene)sulfonamido]-N-(1,3-thiazol-2-...)copy SMILEScopy InChI
Affinity DataKi:  556nM ΔG°:  -35.2kJ/mole IC50: 1.29E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18436(4-methyl-N-{4-methyl-2-[4-(pyrimidin-2-yl)piperazi...)copy SMILEScopy InChI
Affinity DataKi:  975nM ΔG°:  -33.8kJ/mole IC50: 2.45E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18448(2-({4-[(3-methylphenyl)amino]-6-(pyrrolidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataKi:  2.78E+3nM ΔG°:  -31.3kJ/mole IC50: 4.31E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18449(2-({4-[(4-chlorophenyl)amino]-6-(pyrrolidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataKi:  4.23E+3nM ΔG°:  -30.3kJ/mole IC50: 7.73E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18440(4-benzenesulfonamido-N-butylbenzamide | Sulfonamid...)copy SMILEScopy InChI
Affinity DataKi:  7.15E+3nM ΔG°:  -29.0kJ/mole IC50: 2.46E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18441(4-[benzene(methyl)sulfonamido]-N-(5-ethyl-1,3,4-th...)copy SMILEScopy InChI
Affinity DataKi:  8.44E+3nM ΔG°:  -28.6kJ/mole IC50: 2.96E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18445(4-benzenesulfonamido-N-phenylbenzamide | Sulfonami...)copy SMILEScopy InChI
Affinity DataKi:  1.34E+4nM ΔG°:  -27.4kJ/mole IC50: 6.46E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18442(4-[benzene(methyl)sulfonamido]-N-(5-methyl-1,2-oxa...)copy SMILEScopy InChI
Affinity DataKi:  1.92E+4nM ΔG°:  -26.6kJ/mole IC50: 2.52E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18444(4-[benzene(methyl)sulfonamido]-N-(1,3-thiazol-2-yl...)copy SMILEScopy InChI
Affinity DataKi:  2.34E+4nM ΔG°:  -26.1kJ/mole IC50: 3.44E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18446(4-benzenesulfonamido-N-benzylbenzamide | Sulfonami...)copy SMILEScopy InChI
Affinity DataKi:  5.06E+4nM ΔG°:  -24.2kJ/mole IC50: 1.00E+5nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18437(Aminoquinoline compound, 22 | N-{2-[(3-chloropheny...)copy SMILEScopy InChI
Affinity DataKi:  1.22E+5nM ΔG°:  -22.0kJ/molepH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18451(2-({4-[(4-chlorophenyl)amino]-6-(morpholin-4-yl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 4.65E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18450(2-({4-[(3-methylphenyl)amino]-6-(morpholin-4-yl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 4.77E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V1232MPubMed
* indicates data uncertainty>20%