Compile Data Set for Download or QSAR

Found 36 hits of Enzyme Inhibition Constant Data   

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18471(2-[(4-{[2-(tert-butoxy)phenyl]amino}-6-(pyrrolidin...)copy SMILEScopy InChI
Affinity DataIC50: 330nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18480(2-({4-[(2-hydroxyethyl)amino]-6-(pyrrolidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 370nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18447(2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrroli...)copy SMILEScopy InChI
Affinity DataIC50: 700nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18479(4-chloro-2-({4-[(2-hydroxyethyl)amino]-6-(pyrrolid...)copy SMILEScopy InChI
Affinity DataIC50: 730nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18469(2-({4-[(2-ethoxyphenyl)amino]-6-(pyrrolidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 770nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18481(2-({4-[(5-chloro-2-ethoxyphenyl)amino]-6-(pyrrolid...)copy SMILEScopy InChI
Affinity DataIC50: 960nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18483(2-[(4-{[2-(tert-butoxy)-5-chlorophenyl]amino}-6-(p...)copy SMILEScopy InChI
Affinity DataIC50: 1.04E+3nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18465(2-({4-[(2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.08E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18475(2-({4-[(2,5-dimethoxyphenyl)amino]-6-(pyrrolidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 1.53E+3nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18468(2-({4-[(2-hydroxyethyl)amino]-6-(pyrrolidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18478(2-({4-[(2-methoxy-5-phenylphenyl)amino]-6-(pyrroli...)copy SMILEScopy InChI
Affinity DataIC50: 2.22E+3nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18460(2-{[4-(azetidin-1-yl)-6-[(2-methoxyphenyl)amino]-1...)copy SMILEScopy InChI
Affinity DataIC50: 2.31E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18474(2-[(4-{[2-(methylsulfanyl)phenyl]amino}-6-(pyrroli...)copy SMILEScopy InChI
Affinity DataIC50: 2.39E+3nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18477(2-[(4-{[2-methoxy-5-(trifluoromethyl)phenyl]amino}...)copy SMILEScopy InChI
Affinity DataIC50: 2.65E+3nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18473(2-{[4-(pyrrolidin-1-yl)-6-{[2-(trifluoromethoxy)ph...)copy SMILEScopy InChI
Affinity DataIC50: 3.34E+3nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18482(2-[(4-{[5-chloro-2-(propan-2-yloxy)phenyl]amino}-6...)copy SMILEScopy InChI
Affinity DataIC50: 3.44E+3nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18461(2-({4-[(2-methylphenyl)amino]-6-(pyrrolidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 3.94E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18476(2-({4-[(2,4-dimethoxyphenyl)amino]-6-(pyrrolidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 4.90E+3nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18457(2-{[4-(butylamino)-6-[(2-methoxyphenyl)amino]-1,3,...)copy SMILEScopy InChI
Affinity DataIC50: 6.10E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18448(2-({4-[(3-methylphenyl)amino]-6-(pyrrolidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 6.19E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18449(2-({4-[(4-chlorophenyl)amino]-6-(pyrrolidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 6.34E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18464(2-({4-[(3-chlorophenyl)amino]-6-(pyrrolidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 6.69E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18454(1-({4-[(2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 6.80E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18459(2-{[4-(3,3-difluoropyrrolidin-1-yl)-6-[(2-methoxyp...)copy SMILEScopy InChI
Affinity DataIC50: 7.75E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18452(2-N-butyl-4-N-(5-chloro-2-methoxyphenyl)-6-(pyrrol...)copy SMILEScopy InChI
Affinity DataIC50: 7.77E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18466(2-({4-[(3-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 8.25E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18467(2-({4-[(4-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 8.80E+3nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18462(2-({4-[(4-methylphenyl)amino]-6-(pyrrolidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18455(2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(morphol...)copy SMILEScopy InChI
Affinity DataIC50: 1.21E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18484(2-{[4-(phenylamino)-6-(pyrrolidin-1-yl)-1,3,5-tria...)copy SMILEScopy InChI
Affinity DataIC50: 1.65E+4nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18458(2-{[4-(benzylamino)-6-[(2-methoxyphenyl)amino]-1,3...)copy SMILEScopy InChI
Affinity DataIC50: 1.88E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18453(1-({4-[(2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 2.07E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18470(2-({4-[(2-phenoxyphenyl)amino]-6-(pyrrolidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 2.17E+4nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18463(2-({4-[(2-chlorophenyl)amino]-6-(pyrrolidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 2.90E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18456(2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(piperid...)copy SMILEScopy InChI
Affinity DataIC50: 3.11E+4nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
NIH

LigandPNGBDBM18472(2-[(4-{[2-(benzyloxy)phenyl]amino}-6-(pyrrolidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 3.14E+4nMAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81BBWPubMed
* indicates data uncertainty>20%