Compile Data Set for Download or QSAR

Found 33 hits of Enzyme Inhibition Constant Data   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263515(2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-be...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of TEL fused Src-mediated proliferation of TEL-Src transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263515(2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-be...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263516(CHEMBL450092 | N4-(6-(2-(2-chloro-6-methylphenylam...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263516(CHEMBL450092 | N4-(6-(2-(2-chloro-6-methylphenylam...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263513(CHEMBL477172 | N-(2-chloro-6-methylphenyl)-1-(6-(4...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of Lck by lance assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263513(CHEMBL477172 | N-(2-chloro-6-methylphenyl)-1-(6-(4...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263515(2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-be...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of TEL fused Lck-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263515(2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-be...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of TEL fused Lyn-mediated proliferation of TEL-Lyn transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263514(CHEMBL473250 | N-(2-chloro-6-methylphenyl)-1-(6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263514(CHEMBL473250 | N-(2-chloro-6-methylphenyl)-1-(6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263517(CHEMBL448014 | N4-(6-(2-(2-chloro-6-methylphenylam...)copy SMILEScopy InChI
Affinity DataIC50: 119nMAssay Description:Inhibition of TEL fused Lck-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263514(CHEMBL473250 | N-(2-chloro-6-methylphenyl)-1-(6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 147nMAssay Description:Inhibition of TEL fused Src-mediated proliferation of TEL-Src transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263514(CHEMBL473250 | N-(2-chloro-6-methylphenyl)-1-(6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 215nMAssay Description:Inhibition of TEL fused Lyn-mediated proliferation of TEL-Lyn transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263515(2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-be...)copy SMILEScopy InChI
Affinity DataIC50: 356nMAssay Description:Inhibition of TEL fused KDR-mediated proliferation of TEL-KDR transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263517(CHEMBL448014 | N4-(6-(2-(2-chloro-6-methylphenylam...)copy SMILEScopy InChI
Affinity DataIC50: 359nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263348(1-(6-aminopyrimidin-4-yl)-N-(2-chloro-6-methylphen...)copy SMILEScopy InChI
Affinity DataIC50: 438nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263348(1-(6-aminopyrimidin-4-yl)-N-(2-chloro-6-methylphen...)copy SMILEScopy InChI
Affinity DataIC50: 438nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263349(1-(6-aminopyrimidin-4-yl)-N-mesityl-1H-benzo[d]imi...)copy SMILEScopy InChI
Affinity DataIC50: 583nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263476(CHEMBL477590 | N-(2-chloro-6-methylphenyl)-1-(6-(4...)copy SMILEScopy InChI
Affinity DataIC50: 789nMAssay Description:Inhibition of Lck by lance assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263514(CHEMBL473250 | N-(2-chloro-6-methylphenyl)-1-(6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of TEL fused KDR-mediated proliferation of TEL-KDR transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263347(1-(6-aminopyrimidin-4-yl)-N-(2-bromo-4,6-dimethylp...)copy SMILEScopy InChI
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263347(1-(6-aminopyrimidin-4-yl)-N-(2-bromo-4,6-dimethylp...)copy SMILEScopy InChI
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of Lck by lance assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263349(1-(6-aminopyrimidin-4-yl)-N-mesityl-1H-benzo[d]imi...)copy SMILEScopy InChI
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of TEL fused Lck-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263473(CHEMBL477624 | N-(2-chloro-6-methylphenyl)-1-(pyri...)copy SMILEScopy InChI
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of TEL fused Lck-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetInsulin receptor(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263515(2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-be...)copy SMILEScopy InChI
Affinity DataIC50: 2.35E+3nMAssay Description:Inhibition of TEL fused InsR-mediated proliferation of TEL-InsR transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263376(CHEMBL476989 | N-(2-chloro-6-methylphenyl)-1-(6-ch...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Lck by lance assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263474(CHEMBL516114 | N-(2-chloro-6-methylphenyl)-1-(6-mo...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of TEL fused Lck-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263476(CHEMBL477590 | N-(2-chloro-6-methylphenyl)-1-(6-(4...)copy SMILEScopy InChI
Affinity DataIC50: 5.04E+3nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetInsulin receptor(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263514(CHEMBL473250 | N-(2-chloro-6-methylphenyl)-1-(6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 5.17E+3nMAssay Description:Inhibition of TEL fused InsR-mediated proliferation of TEL-InsR transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263376(CHEMBL476989 | N-(2-chloro-6-methylphenyl)-1-(6-ch...)copy SMILEScopy InChI
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263474(CHEMBL516114 | N-(2-chloro-6-methylphenyl)-1-(6-mo...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263475(CHEMBL477589 | N-(2-chloro-6-methylphenyl)-1-(6-(m...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL
LigandPNGBDBM50263475(CHEMBL477589 | N-(2-chloro-6-methylphenyl)-1-(6-(m...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN44WQPubMed
* indicates data uncertainty>20%