Compile Data Set for Download or QSAR

Found 34 hits of Enzyme Inhibition Constant Data   

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274438(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28118(3-cyanoquinoline, 3 | 4-({3-chloro-4-[(1-methyl-1H...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274439(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274204(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274440(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274335(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274333(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274384(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274334(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274332(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274386(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274245(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274437(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274202(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274203(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274244(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:Inhibition of Src (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274243(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:Inhibition of Lyn (unknown origin) in presence of 20 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274242(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of MEK1 (unknown origin) by raf/MEK1/MAPK coupled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 225nMAssay Description:Inhibition of MEK1-mediated ERK phosphorylation in human WM266-4 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KDR (unknown origin) in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of PDK1 (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of B-raf (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 9.17E+3nMAssay Description:Inhibition of IKKbeta (unknown origin) in presence of 2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin) in presence of 25 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of P70S6 (unknown origin) in presence of 2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 2.74E+4nMAssay Description:Inhibition of PKCtheta (unknown origin) in presence of 6 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mTOR (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of AKT (unknown origin) in presence of 20 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of Tpl2 (unknown origin) in presence of 50 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50274385(4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]ph...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MK2 (unknown origin) in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FGDPubMed
* indicates data uncertainty>20%