Compile Data Set for Download or QSAR

Found 16 hits of Enzyme Inhibition Constant Data   

TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276291(CHEMBL472464 | N-benzyl-N-(1'-(2,6-dimethylbenzoyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276259(CHEMBL481068 | exo-N-benzyl-N-((R)-1-(8-(2,6-dimet...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276260((R)-N-benzyl-N-(1-(1-(2,6-dimethylbenzoyl)piperidi...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276290(CHEMBL472260 | N-benzyl-N-(1'-(2,6-dimethylbenzoyl...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276260((R)-N-benzyl-N-(1-(1-(2,6-dimethylbenzoyl)piperidi...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Displacement of [125]Mip1beta form CCR5 receptor (unknown origin) expressed in MIP34.10 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276623((4-((1-benzhydrylazetidin-3-yl)(methyl)amino)piper...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276672((4-(3-benzhydryl-3,8-diazabicyclo[3.2.1]octan-8-yl...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276793(CHEMBL459986 | rac-N-(2-(3-(2,2-diphenylethyl)pipe...)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276792((3-((1-benzhydrylpiperidin-4-yl)(methyl)amino)azet...)copy SMILEScopy InChI
Affinity DataIC50: 102nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276217(CHEMBL471403 | N-((4-benzyl-1'-(2,6-dimethylbenzoy...)copy SMILEScopy InChI
Affinity DataIC50: 145nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276671((4-(8-benzhydryl-3,8-diazabicyclo[3.2.1]octan-3-yl...)copy SMILEScopy InChI
Affinity DataIC50: 313nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276261((S)-N-benzyl-N-(1-(1-(2,6-dimethylbenzoyl)piperidi...)copy SMILEScopy InChI
Affinity DataIC50: 1.23E+3nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276078(CHEMBL471844 | N-((1-(1-(2,6-dimethylbenzoyl)piper...)copy SMILEScopy InChI
Affinity DataIC50: 2.49E+3nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276290(CHEMBL472260 | N-benzyl-N-(1'-(2,6-dimethylbenzoyl...)copy SMILEScopy InChI
Affinity DataIC50: 3.41E+3nMAssay Description:Displacement of [3H]dofetilide form human ERG expressed in HEK239 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276292(CHEMBL471218 | N-benzyl-N-(1-(1-(2,6-dimethylbenzo...)copy SMILEScopy InChI
Affinity DataIC50: 5.80E+3nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50276260((R)-N-benzyl-N-(1-(1-(2,6-dimethylbenzoyl)piperidi...)copy SMILEScopy InChI
Affinity DataIC50: 9.80E+3nMAssay Description:Displacement of [3H]dofetilide form human ERG expressed in HEK239 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095SGPubMed
* indicates data uncertainty>20%