Compile Data Set for Download or QSAR

Found 27 hits of Enzyme Inhibition Constant Data   

TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248322((+/-)-N-((1S)-3-(4-(3-isopropyl-5-methyl-4H-1,2,4-...)copy SMILEScopy InChI
Affinity DataIC50: 0.137nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50334986(4,4-Difluoro-cyclohexanecarboxylic acid {(S)-3-[(1...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248440((+/-)-3,3-difluoro-N-((1S)-3-(4-(3-isopropyl-5-met...)copy SMILEScopy InChI
Affinity DataIC50: 0.380nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248481(3,3-difluoro-N-((1S,3R)-3-(4-(3-isopropyl-5-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.480nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248323((+/-)-N-((1S)-3-(4-(3-isopropyl-5-methyl-4H-1,2,4-...)copy SMILEScopy InChI
Affinity DataIC50: 0.513nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248439((+/-)-4,4-difluoro-N-((1S)-3-(4-(3-isopropyl-5-met...)copy SMILEScopy InChI
Affinity DataIC50: 0.840nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248440((+/-)-3,3-difluoro-N-((1S)-3-(4-(3-isopropyl-5-met...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248530(4,4-difluoro-N-((1S)-3-(3-(5-isopropyl-3-methyl-1H...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248269((+/-)-N-((1S)-3-(4-(3-isopropyl-5-methyl-4H-1,2,4-...)copy SMILEScopy InChI
Affinity DataIC50: 3.11nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248268((+/-)-2-cyclopropyl-N-((1S)-3-(4-(3-isopropyl-5-me...)copy SMILEScopy InChI
Affinity DataIC50: 3.16nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248321((+/-)-N-((1S)-3-(4-(3-isopropyl-5-methyl-4H-1,2,4-...)copy SMILEScopy InChI
Affinity DataIC50: 3.93nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248382((+/-)-1-Oxo-hexahydro-1lambda*4*-thiopyran-4-carbo...)copy SMILEScopy InChI
Affinity DataIC50: 4.87nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248383((+/-)-1,1-Dioxo-hexahydro-1lambda*6*-thiopyran-4-c...)copy SMILEScopy InChI
Affinity DataIC50: 6.12nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248384((+/-)-1-acetyl-N-((1S)-3-(4-(3-isopropyl-5-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 28.7nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248482(4,4-difluoro-N-((1S,3S)-3-(4-(3-isopropyl-5-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 49.9nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248267((+/-)-N-((1S)-3-(4-(3-isopropyl-5-methyl-4H-1,2,4-...)copy SMILEScopy InChI
Affinity DataIC50: 52.8nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248439((+/-)-4,4-difluoro-N-((1S)-3-(4-(3-isopropyl-5-met...)copy SMILEScopy InChI
Affinity DataIC50: 62nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248266((+/-)-3,3,3-trifluoro-N-((1S)-3-(4-(3-isopropyl-5-...)copy SMILEScopy InChI
Affinity DataIC50: 85.3nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248212((+/-)-N-((1S)-3-(4-(3-isopropyl-5-methyl-4H-1,2,4-...)copy SMILEScopy InChI
Affinity DataIC50: 89.2nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248324((+/-)-N-((1S)-3-(4-(3-isopropyl-5-methyl-4H-1,2,4-...)copy SMILEScopy InChI
Affinity DataIC50: 164nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248437((+/-)-N-((1S)-3-(4-(3-isopropyl-5-methyl-4H-1,2,4-...)copy SMILEScopy InChI
Affinity DataIC50: 176nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248438((+/-)-N-((1S)-3-(4-(3-isopropyl-5-methyl-4H-1,2,4-...)copy SMILEScopy InChI
Affinity DataIC50: 187nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248385((+/-)-methyl(1S)-3-(4-(3-isopropyl-5-methyl-4H-1,2...)copy SMILEScopy InChI
Affinity DataIC50: 315nMAssay Description:Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 ex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248439((+/-)-4,4-difluoro-N-((1S)-3-(4-(3-isopropyl-5-met...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248440((+/-)-3,3-difluoro-N-((1S)-3-(4-(3-isopropyl-5-met...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248482(4,4-difluoro-N-((1S,3S)-3-(4-(3-isopropyl-5-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50248481(3,3-difluoro-N-((1S,3R)-3-(4-(3-isopropyl-5-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN96JFPubMed
* indicates data uncertainty>20%