Compile Data Set for Download or QSAR

Found 24 hits of Enzyme Inhibition Constant Data   

TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258790((S)-2-amino-N-(3-(5-(5-(benzo[d]thiazol-7-yl)-1,3,...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258814((S)-2-amino-N-(3-(5-(5-(2-methoxyphenylamino)-1,3,...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258789((S)-2-amino-N-(3-(5-(5-(2-chlorophenyl)-1,3,4-oxad...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258787((S)-2-amino-N-(3-(5-(5-(2-methoxyphenyl)-1,3,4-oxa...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258747((S)-2-amino-N-(3-(5-(5-phenyl-1,3,4-oxadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM27659(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-be...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258815((S)-2-amino-N-(3-(3-methyl-5-(5-phenyl-1,3,4-oxadi...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258788((S)-2-amino-N-(3-(5-(5-(3-methoxyphenyl)-1,3,4-oxa...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258748((S)-2-amino-N-(3-(5-(3-phenyl-1,2,4-oxadiazol-5-yl...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258749((S)-2-amino-N-(3-(5-(5-benzyl-1,3,4-oxadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258859((S)-2-amino-N-(3-(4-(5-phenyl-1,3,4-oxadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 360nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258817((S)-2-amino-N-(3-(1-methyl-4-(5-phenyl-1,3,4-oxadi...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258750((S)-2-amino-N-(3-(5-(5-(pyridin-4-yl)-1,3,4-oxadia...)copy SMILEScopy InChI
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258860((S)-2-amino-N-(3-(5-(5-phenyl-1,3,4-oxadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258816((S)-2-amino-N-(3-(1-methyl-4-(5-phenyl-1,3,4-oxadi...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258862((S)-N1-(3-(5-(5-phenyl-1,3,4-oxadiazol-2-yl)-3-(tr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258861((S)-2-amino-N-methyl-N-(3-(5-(5-phenyl-1,3,4-oxadi...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CARM1 assessed as blockade of histone H3 methylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258790((S)-2-amino-N-(3-(5-(5-(benzo[d]thiazol-7-yl)-1,3,...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PRMT1 by methylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258790((S)-2-amino-N-(3-(5-(5-(benzo[d]thiazol-7-yl)-1,3,...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PRMT3 by methylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258790((S)-2-amino-N-(3-(5-(5-(benzo[d]thiazol-7-yl)-1,3,...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 expressed in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258790((S)-2-amino-N-(3-(5-(5-(benzo[d]thiazol-7-yl)-1,3,...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9 expressed in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258790((S)-2-amino-N-(3-(5-(5-(benzo[d]thiazol-7-yl)-1,3,...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 expressed in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258790((S)-2-amino-N-(3-(5-(5-(benzo[d]thiazol-7-yl)-1,3,...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C19 expressed in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50258790((S)-2-amino-N-(3-(5-(5-(benzo[d]thiazol-7-yl)-1,3,...)copy SMILEScopy InChI
Affinity DataEC50: >2.50E+4nMAssay Description:Inhibition of human PXRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B3170PubMed
* indicates data uncertainty>20%