Compile Data Set for Download or QSAR

Found 92 hits of Enzyme Inhibition Constant Data   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)copy SMILEScopy InChI
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMedDrugBank
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)copy SMILEScopy InChI
Affinity DataKi:  3.40nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMedDrugBank
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataKi:  22.1nMAssay Description:Displacement of [3H]WIN35428 from human recombinant DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMedDrugBank
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319577(3-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiad...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319578((2S)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319582(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiad...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319576(4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol-1(3H...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319575((2S)-(4-[3-(2,5-Difluorophenyl)-2,2-dioxido-2,1,3-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319580((2S)-4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319578((2S)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319587(CHEMBL1084042 | {3-[3-(2-Fluoro-phenyl)-2,2-dioxo-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319581((2S)-(4-[3-(2,6-Difluorophenyl)-2,2-dioxido-2,1,3-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319579(4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol-1(3H...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319577(3-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiad...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319583((2R)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319585((2R)-4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319575((2S)-(4-[3-(2,5-Difluorophenyl)-2,2-dioxido-2,1,3-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319583((2R)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319580((2S)-4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319581((2S)-(4-[3-(2,6-Difluorophenyl)-2,2-dioxido-2,1,3-...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319582(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiad...)copy SMILEScopy InChI
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319602(3-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiad...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319576(4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol-1(3H...)copy SMILEScopy InChI
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319586((2R)-(4-[3-(2,6-Difluorophenyl)-2,2-dioxido-2,1,3-...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319578((2S)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319587(CHEMBL1084042 | {3-[3-(2-Fluoro-phenyl)-2,2-dioxo-...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319590((2S)-(4-[3-(2-Chlorophenyl)-2,2-dioxido-2,1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319588(1-(Cyclopropylamino)-4-(2,2-dioxido-3-phenyl-2,1,3...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319586((2R)-(4-[3-(2,6-Difluorophenyl)-2,2-dioxido-2,1,3-...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319585((2R)-4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)copy SMILEScopy InChI
Affinity DataIC50: 9.40nMAssay Description:Inhibition of SERT-mediated serotonin uptake in human JAR cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMedDrugBank
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319578((2S)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319584((2R)-(4-[3-(2,5-Difluorophenyl)-2,2-dioxido-2,1,3-...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319593((2S)-(4-[3-(2,4-Difluorophenyl)-2,2-dioxido-2,1,3-...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319593((2S)-(4-[3-(2,4-Difluorophenyl)-2,2-dioxido-2,1,3-...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319589((2S)-(4-[3-(3-Methoxyphenyl)-2,2-dioxido-2,1,3-ben...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319596((2S)-(4-[3-(2-Methylphenyl)-2,2-dioxido-2,1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319589((2S)-(4-[3-(3-Methoxyphenyl)-2,2-dioxido-2,1,3-ben...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319590((2S)-(4-[3-(2-Chlorophenyl)-2,2-dioxido-2,1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319584((2R)-(4-[3-(2,5-Difluorophenyl)-2,2-dioxido-2,1,3-...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319595((2S)-(4-[3-(3,4-Difluorophenyl)-2,2-dioxido-2,1,3-...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319595((2S)-(4-[3-(3,4-Difluorophenyl)-2,2-dioxido-2,1,3-...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319594((2R)-(4-[3-(2-Chlorophenyl)-2,2-dioxido-2,1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319599((2S)-(4-[3-(4-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319604((2R)-3-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzo...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319594((2R)-(4-[3-(2-Chlorophenyl)-2,2-dioxido-2,1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319596((2S)-(4-[3-(2-Methylphenyl)-2,2-dioxido-2,1,3-benz...)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319602(3-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiad...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319597((2R)-(4-[3-(3-Methoxyphenyl)-2,2-dioxido-2,1,3-ben...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50319600(2,2-Difluoro-3-[3-(2-fluorophenyl)-2,2-dioxido-2,1...)copy SMILEScopy InChI
Affinity DataIC50: 94nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PC32JRPubMed
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