Compile Data Set for Download or QSAR

Found 38 hits of Enzyme Inhibition Constant Data   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325177(5-methyl-8-(1H-pyrrol-2-yl)-[1,2,4]triazolo[4,3-a]...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325145(5-methyl-8-(1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325161(5-methyl-8-(4-(piperazin-1-ylmethyl)phenyl)-[1,2,4...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325162(5-methyl-8-(3-(piperazin-1-ylmethyl)phenyl)-[1,2,4...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325164(5-methyl-8-(4-(morpholinomethyl)phenyl)-[1,2,4]tri...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325163(5-methyl-8-(4-((4-methylpiperazin-1-yl)methyl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50280450(18-hydroxy-3-methoxy-2-methyl-4-methylamino-(2R,3S...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325147(8-(furan-2-yl)-5-methyl-[1,2,4]triazolo[4,3-a]quin...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325150(8-(4-(2-(diethylamino)ethoxy)phenyl)-5-methyl-[1,2...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325169(8-(4-(hydroxymethyl)phenyl)-5-methyl-[1,2,4]triazo...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50280450(18-hydroxy-3-methoxy-2-methyl-4-methylamino-(2R,3S...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325171(5-METHYL-8-PYRIDIN-4-YL[1,2,4]TRIAZOLO[4,3-A]QUINO...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325158(CHEMBL1223317 | N-ethyl-4-(5-methyl-1-oxo-1,2-dihy...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325175(5-methyl-8-(thiophen-2-yl)-[1,2,4]triazolo[4,3-a]q...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325144(5-methyl-8-(1H-pyrrol-3-yl)-[1,2,4]triazolo[4,3-a]...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325151(5-methyl-8-(4-(2-morpholinoethoxy)phenyl)-[1,2,4]t...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325155(4-(5-methyl-1-oxo-1,2-dihydro-[1,2,4]triazolo[4,3-...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325165(5-methyl-8-(4-((methylamino)methyl)phenyl)-[1,2,4]...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325168(8-(3-(hydroxymethyl)phenyl)-5-methyl-[1,2,4]triazo...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325156(8-(4-hydroxy-3-methylphenyl)-5-methyl-[1,2,4]triaz...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325154(5-methyl-8-(4-(morpholine-4-carbonyl)phenyl)-[1,2,...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325176(5-methyl-8-(4-methylthiophen-2-yl)-[1,2,4]triazolo...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325152(5-methyl-8-(4-(methylsulfinyl)phenyl)-[1,2,4]triaz...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50026043(CHEMBL1223166)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325159(4-(5-methyl-1-oxo-1,2-dihydro-[1,2,4]triazolo[4,3-...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325172(5-methyl-8-(pyridin-3-yl)-[1,2,4]triazolo[4,3-a]qu...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325146(8-(1H-imidazol-4-yl)-5-methyl-[1,2,4]triazolo[4,3-...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325143(8-(3-hydroxyphenyl)-5-methyl-[1,2,4]triazolo[4,3-a...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325166(2-(4-(5-methyl-1-oxo-1,2-dihydro-[1,2,4]triazolo[4...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325157(CHEMBL1223248 | N-(4-(5-methyl-1-oxo-1,2-dihydro-[...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325149(8-(4-methoxyphenyl)-5-methyl-[1,2,4]triazolo[4,3-a...)copy SMILEScopy InChI
Affinity DataIC50: 520nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325170(8-(2-(hydroxymethyl)phenyl)-5-methyl-[1,2,4]triazo...)copy SMILEScopy InChI
Affinity DataIC50: 690nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325153(CHEMBL1223245 | N-methyl-4-(5-methyl-1-oxo-1,2-dih...)copy SMILEScopy InChI
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325173(5-methyl-8-(pyrazin-2-yl)-[1,2,4]triazolo[4,3-a]qu...)copy SMILEScopy InChI
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325148(8-(furan-3-yl)-5-methyl-[1,2,4]triazolo[4,3-a]quin...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325174(5-methyl-8-(thiazol-2-yl)-[1,2,4]triazolo[4,3-a]qu...)copy SMILEScopy InChI
Affinity DataIC50: 2.96E+3nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325167(8-(4-(methoxymethyl)phenyl)-5-methyl-[1,2,4]triazo...)copy SMILEScopy InChI
Affinity DataIC50: 3.49E+3nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325160(8-(2-aminophenyl)-5-methyl-[1,2,4]triazolo[4,3-a]q...)copy SMILEScopy InChI
Affinity DataIC50: 2.44E+4nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3SJZPubMed
* indicates data uncertainty>20%