Compile Data Set for Download or QSAR

Found 22 hits of Enzyme Inhibition Constant Data   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human TRKAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343723((S)-6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-fluor...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343727((S)-5-chloro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of JAK3 after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of JAK3 after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human JAK3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of human RETMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343727((S)-5-chloro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of JAK3 after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 115nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 129nMAssay Description:Inhibition of human Pyk2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 174nMAssay Description:Inhibition of human CDK2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343723((S)-6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-fluor...)copy SMILEScopy InChI
Affinity DataIC50: 183nMAssay Description:Inhibition of JAK3 after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 215nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 224nMAssay Description:Inhibition of human MuSkMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343724((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 688nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343724((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 1.74E+3nMAssay Description:Inhibition of JAK3 after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EphB2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetInsulin receptor(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human InsRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
* indicates data uncertainty>20%