Found 39 hits of Enzyme Inhibition Constant Data
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataKi: 170nMAssay Description:Competitive inhibition of ALK phosphorylation by Lineweaver-Burk plot analysisChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 11.4nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 11.6nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 18.5nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 26.2nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 33.4nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 37.4nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of KDR assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of Src assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of INSR assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of FGFR2 assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of Abl assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 660nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 770nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 850nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IGF1R assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 2.47E+3nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.47E+3nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of c-Met assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetProtein kinase C alpha type(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCalpha assessed as FLC-SIYRRGSRRWRKL peptide phosphorylation by fluorescence polarization assayChecked by AuthorMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Raf1 assessed as MEK1/2 phosphorylation by fluorescence polarization assayChecked by AuthorMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Kit assessed as biotin-HEQEDEPEGDYFEWLEPE peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of c-Met assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of AKT1 assessed as FI-H1-peptide phosphorylation by fluorescence polarization assayChecked by AuthorMore data for this Ligand-Target Pair
TargetProtein kinase C beta type(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCbeta2 assessed as FLC-SIYRRGSRRWRKL peptide phosphorylation by fluorescence polarization assayChecked by AuthorMore data for this Ligand-Target Pair
TargetProtein kinase C beta type(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCbeta1 assessed as FLC-SIYRRGSRRWRKL peptide phosphorylation by fluorescence polarization assayChecked by AuthorMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Chugai Pharmaceutical Co. Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of HER2 assessed as biotin-HEQEDEPEGDYFEWLEPE peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of aurora A assessed as FLC-LRRASLG peptide phosphorylation by fluorescence polarization assayChecked by AuthorMore data for this Ligand-Target Pair