Compile Data Set for Download or QSAR

Found 11 hits of Enzyme Inhibition Constant Data   

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center for Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM50182801((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center for Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM18428(Aminoquinoline compound, 1 | N-[4-methyl-2-(morpho...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70GZ1PubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center for Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM18438(4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70GZ1PubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center for Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM50396168(CHEMBL1361379)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70GZ1PubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center for Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM50068039(1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)...)copy SMILEScopy InChI
Affinity DataIC50: 360nMAssay Description:Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70GZ1PubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center for Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM18447(2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrroli...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70GZ1PubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center for Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM50068039(1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)...)copy SMILEScopy InChI
Affinity DataIC50: 710nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70GZ1PubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center for Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM18428(Aminoquinoline compound, 1 | N-[4-methyl-2-(morpho...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70GZ1PubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center for Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM18438(4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70GZ1PubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center for Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM18447(2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrroli...)copy SMILEScopy InChI
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70GZ1PubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
National Center for Advancing Translation Sciences

Curated by ChEMBL
LigandPNGBDBM50396168(CHEMBL1361379)copy SMILEScopy InChI
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70GZ1PubMed
* indicates data uncertainty>20%