Compile Data Set for Download or QSAR

Found 31 hits of Enzyme Inhibition Constant Data   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448144(CHEMBL3122212)copy SMILEScopy InChI
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448157(CHEMBL3122215)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448161(CHEMBL3122210)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448159(CHEMBL3122213)copy SMILEScopy InChI
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448149(CHEMBL3122224)copy SMILEScopy InChI
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448163(CHEMBL3122208)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448162(CHEMBL3122209)copy SMILEScopy InChI
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448158(CHEMBL3122214)copy SMILEScopy InChI
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448150(CHEMBL3122225)copy SMILEScopy InChI
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448154(CHEMBL3122218)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448148(CHEMBL3122223)copy SMILEScopy InChI
Affinity DataKi:  7.80nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448155(CHEMBL3122217)copy SMILEScopy InChI
Affinity DataKi:  8.10nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448153(CHEMBL3122219)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448160(CHEMBL3122211)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448164(CHEMBL3122207)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448156(CHEMBL3122216)copy SMILEScopy InChI
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448152(CHEMBL3122221)copy SMILEScopy InChI
Affinity DataKi:  42nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448147(CHEMBL3122222)copy SMILEScopy InChI
Affinity DataKi:  55nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448145(CHEMBL3122206)copy SMILEScopy InChI
Affinity DataKi:  58nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448151(CHEMBL3122226)copy SMILEScopy InChI
Affinity DataKi:  114nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448146(CHEMBL3122205)copy SMILEScopy InChI
Affinity DataKi:  899nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448149(CHEMBL3122224)copy SMILEScopy InChI
Affinity DataIC50: 5.87E+3nMAssay Description:Negative allosteric modulation of human mGluR1 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448144(CHEMBL3122212)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE11 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448148(CHEMBL3122223)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+4nMAssay Description:Negative allosteric modulation of human mGluR1 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448150(CHEMBL3122225)copy SMILEScopy InChI
Affinity DataIC50: 2.98E+4nMAssay Description:Negative allosteric modulation of human mGluR1 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448144(CHEMBL3122212)copy SMILEScopy InChI
Affinity DataIC50: 3.05E+4nMAssay Description:Negative allosteric modulation of human mGluR1 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448152(CHEMBL3122221)copy SMILEScopy InChI
Affinity DataIC50: 3.57E+4nMAssay Description:Negative allosteric modulation of human mGluR1 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448147(CHEMBL3122222)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human mGluR1 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448151(CHEMBL3122226)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human mGluR1 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448145(CHEMBL3122206)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human mGluR1 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50448146(CHEMBL3122205)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Negative allosteric modulation of human mGluR1 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90WRPubMed
* indicates data uncertainty>20%