Compile Data Set for Download or QSAR

Found 25 hits of Enzyme Inhibition Constant Data   

TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088291(CHEMBL3427770)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088342(CHEMBL3427744)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088297(CHEMBL3427748)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088296(CHEMBL3427759)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088291(CHEMBL3427770)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT2 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088300(CHEMBL3427752)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088292(CHEMBL3427768)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088294(CHEMBL3427761)copy SMILES
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088331(CHEMBL3427750)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088293(CHEMBL3427762)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088295(CHEMBL3427760)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088296(CHEMBL3427759)copy SMILEScopy InChI
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT2 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088299(CHEMBL3427754)copy SMILEScopy InChI
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)copy SMILEScopy InChI
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT2 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088292(CHEMBL3427768)copy SMILEScopy InChI
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT2 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088293(CHEMBL3427762)copy SMILEScopy InChI
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT2 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088294(CHEMBL3427761)copy SMILES
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT2 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088295(CHEMBL3427760)copy SMILEScopy InChI
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT2 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088297(CHEMBL3427748)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088297(CHEMBL3427748)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088297(CHEMBL3427748)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088297(CHEMBL3427748)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088298(CHEMBL3427758)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
MethylGene Inc.

Curated by ChEMBL
LigandPNGBDBM50088297(CHEMBL3427748)copy SMILEScopy InChI
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of His-tagged human recombinant SIRT2 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63PN0PubMed
* indicates data uncertainty>20%