Found 23 hits of Enzyme Inhibition Constant Data
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 0.230nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of rat COMTMore data for this Ligand-Target Pair
3D Structure (crystal)TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 9.90nMAssay Description:Inhibition of DAT in Wistar rat synaptosomes assessed as [3H]-DA reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human DA transporter assessed as reduction in [3H]-DA reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of DAT in Wistar rat synaptosomes assessed as [3H]-DA reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human DA transporter assessed as reduction in [3H]-DA reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of DAT in Wistar rat synaptosomes assessed as [3H]-DA reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant human DA transporter assessed as reduction in [3H]-DA reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human DA transporter assessed as reduction in [3H]-DA reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of DAT in Wistar rat synaptosomes assessed as [3H]-DA reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 151nMAssay Description:Inhibition of rat COMTMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
School of Medicine of University of Electronic Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 690nMAssay Description:Inhibition of human ERG channel tail currentMore data for this Ligand-Target Pair
