Compile Data Set for Download or QSAR

Found 24 hits of Enzyme Inhibition Constant Data   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of His-tagged full length human recombinant wild type ABL expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of full length GST-tagged human recombinant BRAF V600E mutant expressed in baculovirus using Fluorescein-MAP2K1 as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of GST-tagged human recombinant EGFR (668 to1210 residues) expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of GST-tagged full length human recombinant HCK expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of GST-tagged full length human recombinant LYNA expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of full length His-tagged human recombinant cSRC expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of GST-tagged full length human recombinant YES expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of His-tagged full length human recombinant ABL G250E mutant expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of full length GST-tagged human recombinant PDGFRalpha expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of His-tagged full length human recombinant ABL Y253F mutant expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 62nMAssay Description:Inhibition of GST-tagged full length human recombinant FRK expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 69nMAssay Description:Inhibition of His-tagged full length human recombinant LCK expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 73nMAssay Description:Inhibition of His-tagged full length human recombinant ABL E255K mutant expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 112nMAssay Description:Inhibition of GST-tagged human recombinant EGFR T790M mutant (668 to 1210 residues) expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataIC50: 131nMAssay Description:Inhibition of His-tagged full length human recombinant FYN expressed in baculovirus using Fluorescein-Poly GT as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataEC50:  0.0500nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)copy SMILEScopy InChI
Affinity DataEC50:  34nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataEC50:  0.0400nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)copy SMILEScopy InChI
Affinity DataEC50:  0.0400nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataEC50:  0.300nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
OriBase Pharma

Curated by ChEMBL
LigandPNGBDBM50172492(CHEMBL3808884)copy SMILEScopy InChI
Affinity DataEC50:  1.80nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VTRPubMed
* indicates data uncertainty>20%