Compile Data Set for Download or QSAR

Found 9 hits of Enzyme Inhibition Constant Data   

TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ERBB4 cytoplasmic domain (708 to 993 residues) expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ0680PubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)copy SMILEScopy InChI
Affinity DataIC50: 8.10nMAssay Description:Inhibition of full-length recombinant human His-tagged BLK expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ0680PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)copy SMILEScopy InChI
Affinity DataIC50: 8.10nMAssay Description:Inhibition of recombinant human IgG1 Fc-tagged ERBB2 cytoplasmic domain (676 to 1255 residues) expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ0680PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)copy SMILEScopy InChI
Affinity DataIC50: 8.30nMAssay Description:Inhibition of recombinant human GST-tagged EGFR cytoplasmic domain expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ0680PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of full-length recombinant human His-tagged BTK cytoplasmic domain expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ0680PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)copy SMILEScopy InChI
Affinity DataIC50: 111nMAssay Description:Inhibition of full-length recombinant human His-tagged BMX expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ0680PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)copy SMILEScopy InChI
Affinity DataIC50: 161nMAssay Description:Inhibition of full-length recombinant human His-tagged MEK1 expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ0680PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50054654(CHEMBL4068839)copy SMILEScopy InChI
Affinity DataEC50:  70nMAssay Description:Inhibition of wild-type EGFR (unknown origin) autophosphorylation at Y1068 expressed in mouse BAF3 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ0680PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
High Magnetic Field Laboratory

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)copy SMILEScopy InChI
Affinity DataEC50:  43nMAssay Description:Inhibition of wild-type EGFR (unknown origin) autophosphorylation at Y1068 expressed in mouse BAF3 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
* indicates data uncertainty>20%