Compile Data Set for Download or QSAR

Found 86 hits of Enzyme Inhibition Constant Data   

TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Irreversible inhibition of human FGFR2 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Irreversible inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated with enzyme followed by peptide substrate addition by ca...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)copy SMILEScopy InChI
Affinity DataKi:  2.20nMAssay Description:Irreversible inhibition of human FGFR3 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)copy SMILEScopy InChI
Affinity DataKi:  73nMAssay Description:Irreversible inhibition of human FGFR4 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM287008(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286381(8-(2-((1-acryloylpiperidin-3-yl)oxy)ethyl)-6-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238813(CHEMBL4083740)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238811(CHEMBL4073347)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238823(CHEMBL4086567)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM287067(8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238809(CHEMBL4084708)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM287008(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM287067(8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238806(CHEMBL4083151)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238804(CHEMBL4099578)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human FGFR2 preincubated for 15 mins followed by peptide substrate addition measured after 3 hrs by caliper capillary electrophoresis m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238805(CHEMBL4061286)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238805(CHEMBL4061286)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238818(CHEMBL4064081)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238818(CHEMBL4064081)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238824(CHEMBL4064756)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238803(CHEMBL4066763)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238803(CHEMBL4066763)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286523(8-(2-((1-acryloylpyrrolidin-3-yl)oxy)ethyl)-6-(2,6...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238821(CHEMBL4088057)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238816(CHEMBL4084079)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238821(CHEMBL4088057)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238810(CHEMBL4092456)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238810(CHEMBL4092456)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238802(CHEMBL4095783)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238804(CHEMBL4099578)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238812(CHEMBL4100201)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM287559(8-(2-((1-acryloylpiperidin-4-yl)(methyl)amino)ethy...)copy SMILEScopy InChI
Affinity DataIC50: 4.10nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)copy SMILEScopy InChI
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human FGFR3 preincubated for 15 mins followed by peptide substrate addition measured after 3 hrs by caliper capillary electrophoresis m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM287559(8-(2-((1-acryloylpiperidin-4-yl)(methyl)amino)ethy...)copy SMILEScopy InChI
Affinity DataIC50: 4.10nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238820(CHEMBL4072676)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238814(CHEMBL4085605)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286381(8-(2-((1-acryloylpiperidin-3-yl)oxy)ethyl)-6-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 5.60nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238802(CHEMBL4095783)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286523(8-(2-((1-acryloylpyrrolidin-3-yl)oxy)ethyl)-6-(2,6...)copy SMILEScopy InChI
Affinity DataIC50: 7.80nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)copy SMILEScopy InChI
Affinity DataIC50: 8.10nMAssay Description:Inhibition of human CSF1R preincubated for 15 mins followed by peptide substrate addition measured after 3 hrs by caliper capillary electrophoresis m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238808(CHEMBL4102642)copy SMILEScopy InChI
Affinity DataIC50: 9.40nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238808(CHEMBL4102642)copy SMILEScopy InChI
Affinity DataIC50: 9.40nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238815(CHEMBL4068712)copy SMILEScopy InChI
Affinity DataIC50: 9.40nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238806(CHEMBL4083151)copy SMILEScopy InChI
Affinity DataIC50: 9.5nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50238809(CHEMBL4084708)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53P3HPubMed
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