Compile Data Set for Download or QSAR

Found 29 hits of Enzyme Inhibition Constant Data   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250878(CHEMBL4074540)copy SMILEScopy InChI
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of TNKS2 (unknown origin) expressed in HEK293 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 24 hrs by luc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human 6xHis-tagged TNKS1 ART domain (1030 to 1317 residues) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human 6xHis-tagged TNKS1 ART domain (1030 to 1317 residues) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of TNKS2 (unknown origin) transfected in human SW480 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 48 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250876(CHEMBL4102763)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of TNKS2 (unknown origin) expressed in HEK293 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 24 hrs by luc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250878(CHEMBL4074540)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of TNKS2 (unknown origin) expressed in HEK293 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 24 hrs by luc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250876(CHEMBL4102763)copy SMILEScopy InChI
Affinity DataIC50: 330nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250879(CHEMBL4064869)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250878(CHEMBL4074540)copy SMILEScopy InChI
Affinity DataIC50: 410nMAssay Description:Inhibition of TNKS2 (unknown origin) transfected in human SW480 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 48 hrs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250877(CHEMBL4084811)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250877(CHEMBL4084811)copy SMILEScopy InChI
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of TNKS2 (unknown origin) expressed in HEK293 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 24 hrs by luc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250876(CHEMBL4102763)copy SMILEScopy InChI
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of TNKS2 (unknown origin) transfected in human SW480 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 48 hrs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250877(CHEMBL4084811)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of TNKS2 (unknown origin) transfected in human SW480 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 48 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PARP16 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PARP14 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetProtein mono-ADP-ribosyltransferase PARP15(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PARP15 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PARP10 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250879(CHEMBL4064869)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TNKS2 (unknown origin) expressed in HEK293 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 24 hrs by luc...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP12(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PARP12 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human PARP1 expressed in Escherichia coli using NAD+ as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cell expression system using NAD+ as substrate after 4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetProtein mono-ADP-ribosyltransferase PARP4(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human PARP4 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)

Curated by ChEMBL
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human PARP3 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
* indicates data uncertainty>20%