Compile Data Set for Download or QSAR

Found 83 hits of Enzyme Inhibition Constant Data   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM377836(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(4...)copy SMILEScopy InChI
Affinity DataIC50: 0.180nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521321(CHEMBL4442732)copy SMILEScopy InChI
Affinity DataIC50: 0.25nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521322(CHEMBL4436118)copy SMILEScopy InChI
Affinity DataIC50: 0.370nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521317(CHEMBL4559065)copy SMILEScopy InChI
Affinity DataIC50: 0.410nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50512857(CHEMBL4456283 | US10815213, Example 15)copy SMILEScopy InChI
Affinity DataIC50: 0.640nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521316(CHEMBL4560385)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521315(CHEMBL4469663)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human B cells assessed as reduction in cell proliferation pretreated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50512857(CHEMBL4456283 | US10815213, Example 15)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human B cells assessed as reduction in cell proliferation pretreated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521318(CHEMBL4440096 | US10815213, Example 151)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521312(CHEMBL4456974 | US10815213, Example 116)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521314(CHEMBL4556666 | US10815213, Example 145)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521316(CHEMBL4560385)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human B cells assessed as reduction in cell proliferation pretreated for 30 mins followed...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521322(CHEMBL4436118)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521313(CHEMBL4572913)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521322(CHEMBL4436118)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Inhibition of full-length recombinant human C-terminal His-tagged SRC cytoplasmic domain expressed in baculovirus expression system using FAM-Srctide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521311(CHEMBL4591391 | US10815213, Example 150)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521315(CHEMBL4469663)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM377824((R)-5-amino-3-(4-((5-chloro-3-fluoropyridin-2-yl)o...)copy SMILEScopy InChI
Affinity DataIC50: 7.60nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM377836(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(4...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human EGFR cytoplasmic domain expressed in baculovirus expression system using FITC-C6-KKAEEEEYFELVAKK-NH2 as substrate preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521312(CHEMBL4456974 | US10815213, Example 116)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human B cells assessed as reduction in cell proliferation pretreated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521321(CHEMBL4442732)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human EGFR cytoplasmic domain expressed in baculovirus expression system using FITC-C6-KKAEEEEYFELVAKK-NH2 as substrate preincubated fo...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM377824((R)-5-amino-3-(4-((5-chloro-3-fluoropyridin-2-yl)o...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human B cells assessed as reduction in cell proliferation pretreated for 30 mins followed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50512857(CHEMBL4456283 | US10815213, Example 15)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in anti-human IgE antibody-stimulated histamine release pretreated for 2 hrs followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521321(CHEMBL4442732)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of human EGFR cytoplasmic domain expressed in baculovirus expression system using FITC-C6-KKAEEEEYFELVAKK-NH2 as substrate preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521318(CHEMBL4440096 | US10815213, Example 151)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521312(CHEMBL4456974 | US10815213, Example 116)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of CD69 expression on B cells pretreated for 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521312(CHEMBL4456974 | US10815213, Example 116)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of full-length recombinant human C-terminal His-tagged SRC cytoplasmic domain expressed in baculovirus expression system using FAM-Srctide...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521312(CHEMBL4456974 | US10815213, Example 116)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in anti-human IgE antibody-stimulated histamine release pretreated for 2 hrs followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521316(CHEMBL4560385)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521315(CHEMBL4469663)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of CD69 expression on B cells pretreated for 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50512857(CHEMBL4456283 | US10815213, Example 15)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of CD69 expression on B cells pretreated for 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50512857(CHEMBL4456283 | US10815213, Example 15)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM377824((R)-5-amino-3-(4-((5-chloro-3-fluoropyridin-2-yl)o...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in anti-human IgE antibody-stimulated histamine release pretreated for 2 hrs followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521316(CHEMBL4560385)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of CD69 expression on B cells pretreated for 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521319(CHEMBL4548556)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:Inhibition of full-length human His-tagged BTK expressed in baculovirus expression system using FAM-Srctide peptide as substrate preincubated for 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521316(CHEMBL4560385)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in anti-human IgE antibody-stimulated histamine release pretreated for 2 hrs followed by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521313(CHEMBL4572913)copy SMILEScopy InChI
Affinity DataIC50: 65nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521319(CHEMBL4548556)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM377836(1-[(3R)-1-acryloyl piperidin-3-yl]-5-amino-3-[4-(4...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibition of full-length recombinant human C-terminal His-tagged SRC cytoplasmic domain expressed in baculovirus expression system using FAM-Srctide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM377824((R)-5-amino-3-(4-((5-chloro-3-fluoropyridin-2-yl)o...)copy SMILEScopy InChI
Affinity DataIC50: 89nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of CD69 expression on B cells pretreated for 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521314(CHEMBL4556666 | US10815213, Example 145)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521315(CHEMBL4469663)copy SMILEScopy InChI
Affinity DataIC50: 92nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521315(CHEMBL4469663)copy SMILEScopy InChI
Affinity DataIC50: 95nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in anti-human IgE antibody-stimulated histamine release pretreated for 2 hrs followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521317(CHEMBL4559065)copy SMILEScopy InChI
Affinity DataIC50: 115nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521313(CHEMBL4572913)copy SMILEScopy InChI
Affinity DataIC50: 149nMAssay Description:Inhibition of human EGFR cytoplasmic domain expressed in baculovirus expression system using FITC-C6-KKAEEEEYFELVAKK-NH2 as substrate preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50521311(CHEMBL4591391 | US10815213, Example 150)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of full-length human C-terminal His6-tagged BTK C481S mutant expressed in Sf9 insect cells using FAM-Srctide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8Q30PubMed
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