Compile Data Set for Download or QSAR

Found 23 hits of Enzyme Inhibition Constant Data   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)copy SMILEScopy InChI
Affinity DataIC50: 0.501nMAssay Description:Inhibition of mGLU5 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50505077(CHEMBL4588064)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50391946(CHEMBL2147763)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50391948(CHEMBL2147767)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50391938(CHEMBL2147845)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50113472(CHEMBL3603919 | US10246432, Example 2 | US10584111...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Inhibition of mGLU5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50113467(CHEMBL3603914 | US10246432, Example 14 | US1058411...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of mGLU5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50505076(CHEMBL4530560)copy SMILEScopy InChI
Affinity DataIC50: 7.70nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50113471(CHEMBL3603918)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of mGLU5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50505078(CHEMBL4590482)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50391944(CHEMBL2147769)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50391949(CHEMBL2147768)copy SMILEScopy InChI
Affinity DataIC50: 92nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50505075(CHEMBL4443751)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM50391945(CHEMBL2147770)copy SMILEScopy InChI
Affinity DataIC50: 447nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)copy SMILEScopy InChI
Affinity DataKd:  0.794nMAssay Description:Binding affinity to DDR1 (unknown origin)More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)copy SMILEScopy InChI
Affinity DataKd:  13nMAssay Description:Binding affinity to KIT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)copy SMILEScopy InChI
Affinity DataKd:  10nMAssay Description:Binding affinity to ABL2 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)copy SMILEScopy InChI
Affinity DataKd:  3.16E+3nMAssay Description:Binding affinity to p38alpha (unknown origin)More data for this Ligand-Target Pair
TargetLysine--tRNA ligase(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)copy SMILEScopy InChI
Affinity DataKd:  3.16E+3nMAssay Description:Binding affinity to SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)copy SMILEScopy InChI
Affinity DataKd:  3.98E+4nMAssay Description:Binding affinity to cSRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29Z9851PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)copy SMILEScopy InChI
Affinity DataKd:  40nMAssay Description:Binding affinity to LCK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)copy SMILEScopy InChI
Affinity DataKd:  1nMAssay Description:Binding affinity to ABL1 (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cresset

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)copy SMILEScopy InChI
Affinity DataKd:  10nMAssay Description:Binding affinity to CSF1R (unknown origin)More data for this Ligand-Target Pair
* indicates data uncertainty>20%