Found 14 hits of Enzyme Inhibition Constant Data
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 0.670nMAssay Description:Inhibition of CCDC6/RET in human TPC1 cells assessed as reduction in cell proliferation supplemented with fresh medium containing compound for every ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 0.670nMAssay Description:Inhibition of RET isoform 9 C634W mutant in human TT cells assessed as reduction in cell proliferation supplemented with fresh medium containing comp...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 0.670nMAssay Description:Inhibition of RET isoform 9 M918T mutant in human MZ-CRC-1 cells assessed as reduction in cell proliferation supplemented with fresh medium containin...More data for this Ligand-Target Pair
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 0.670nMAssay Description:Inhibition of CCDC6/RET in human LC2/ad cells assessed as reduction in cell proliferation supplemented with fresh medium containing compound for ever...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human GST-tagged RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus expression system using 5'FAM-EPLYW...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of RET isoform 15 M918T mutant (unknown origin) expressed in mouse BAF3 cells assessed as reduction in cell proliferation supplemented wit...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of RET isoform 15 C634R mutant (unknown origin) expressed in mouse BAF3 cells assessed as reduction in cell proliferation supplemented wit...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human His-tagged VEGFR2 cytoplasmic domain (789 to 1356 residues) expressed in baculovirus expression system using peptide ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of RET isoform 9 C634R mutant (unknown origin) expressed in mouse NIH/3T3 cells assessed as reduction in cell proliferation supplemented w...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human N-terminal GST/His-tagged RET V804M mutant (658 to 1114 residues) expressed in Sf9 insect cells using 5'FAM-EPLYWSFPA...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human His-tagged TRKA cytoplasmic domain (441 to 796 residues) expressed in baculovirus expression system using peptide sub...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus expression system using peptide su...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Universit£ di Napoli "Federico II"
Curated by ChEMBL
Affinity DataIC50: 7.57E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
