Compile Data Set for Download or QSAR

Found 8 hits of Enzyme Inhibition Constant Data   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human ABL T315I mutant using EAIYAAPFAKKK substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human LYN using poly(Glu,Tyr)4:1 substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41W0SPubMedDrugBank
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human c-SRC using poly(Glu,Tyr)4:1 substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41W0SPubMedDrugBank
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50542209(CHEMBL4640401)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human ABL T315I mutant using EAIYAAPFAKKK substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41W0SPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of human VEGFR2 using MBP substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41W0SPubMedDrugBank
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50542209(CHEMBL4640401)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of human LYN using poly(Glu,Tyr)4:1 substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41W0SPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50542209(CHEMBL4640401)copy SMILEScopy InChI
Affinity DataIC50: 441nMAssay Description:Inhibition of human VEGFR2 using MBP substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41W0SPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50542209(CHEMBL4640401)copy SMILEScopy InChI
Affinity DataIC50: 2.58E+3nMAssay Description:Inhibition of human c-SRC using poly(Glu,Tyr)4:1 substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41W0SPubMed
* indicates data uncertainty>20%