Compile Data Set for Download or QSAR

Found 7 hits of Enzyme Inhibition Constant Data   

TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50051747(5-Amino-2-{4-[(2-amino-4-hydroxy-5,6,7,8-tetrahydr...)copy SMILEScopy InChI
Affinity DataKi:  200nMAssay Description:Inhibitory activity against mammalian Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2000158PubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)copy SMILEScopy InChI
Affinity DataIC50: 0.820nMAssay Description:Inhibitory concentration against dihydrofolate reductase (DHFR) enzyme isolated from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50011886(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against dihydrofolate reductase enzyme (DHFR) enzyme isolated from CCRF-CEM human leukemia cells. value mentioned is from li...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2000158PubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50051746(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibitory concentration against dihydrofolate reductase enzyme (DHFR) enzyme isolated from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2000158PubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50011886(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibitory concentration against dihydrofolate reductase enzyme (DHFR) enzyme isolated from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2000158PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50011886(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)copy SMILEScopy InChI
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibitory concentration against human Folyl-polyglutamate synthase isolated from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2000158PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50051746(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibitory concentration against human Folyl-polyglutamate synthase isolated from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2000158PubMed
* indicates data uncertainty>20%