Compile Data Set for Download or QSAR

Found 35 hits of Enzyme Inhibition Constant Data   

TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50052524((S)-N-((S)-1-{[(S)-1-({[(S)-1-((S)-1-Carbamoyl-3-m...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070355(3-(3,4-dichlorophenyl)-3-{3-[1-methylsulfonylspiro...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070351(1-(1-{3-[1-Benzoyl-3-(3,4-dichloro-phenyl)-piperid...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070352(1-benzyl-5-(3,4-dichlorophenyl)-5-{3-[1-methylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070358(8-{3-[1-Benzyl-3-(3,4-dichloro-phenyl)-6-oxo-piper...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070360(3-(3,4-dichlorophenyl)-3-[3-spiro[2,3-dihydro-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50079412((NKB)Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 |...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070356(5-[3-(4-Acetyl-4-phenyl-piperidin-1-yl)-propyl]-1-...)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070353(1-(1-{3-[1-Benzyl-3-(3,4-dichloro-phenyl)-6-oxo-pi...)copy SMILEScopy InChI
Affinity DataIC50: 6.40nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070354(8-{3-[1-Benzoyl-3-(3,4-dichloro-phenyl)-piperidin-...)copy SMILEScopy InChI
Affinity DataIC50: 6.80nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070359(1-(1-{3-[1-Benzoyl-3-(3,4-dichloro-phenyl)-piperid...)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070356(5-[3-(4-Acetyl-4-phenyl-piperidin-1-yl)-propyl]-1-...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070352(1-benzyl-5-(3,4-dichlorophenyl)-5-{3-[1-methylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50001447(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070354(8-{3-[1-Benzoyl-3-(3,4-dichloro-phenyl)-piperidin-...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070354(8-{3-[1-Benzoyl-3-(3,4-dichloro-phenyl)-piperidin-...)copy SMILEScopy InChI
Affinity DataIC50: 108nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50001450((SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH...)copy SMILEScopy InChI
Affinity DataIC50: 125nMAssay Description:Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070358(8-{3-[1-Benzyl-3-(3,4-dichloro-phenyl)-6-oxo-piper...)copy SMILEScopy InChI
Affinity DataIC50: 127nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070355(3-(3,4-dichlorophenyl)-3-{3-[1-methylsulfonylspiro...)copy SMILEScopy InChI
Affinity DataIC50: 177nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070360(3-(3,4-dichlorophenyl)-3-[3-spiro[2,3-dihydro-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 204nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070360(3-(3,4-dichlorophenyl)-3-[3-spiro[2,3-dihydro-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 272nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070359(1-(1-{3-[1-Benzoyl-3-(3,4-dichloro-phenyl)-piperid...)copy SMILEScopy InChI
Affinity DataIC50: 348nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070359(1-(1-{3-[1-Benzoyl-3-(3,4-dichloro-phenyl)-piperid...)copy SMILEScopy InChI
Affinity DataIC50: 379nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070351(1-(1-{3-[1-Benzoyl-3-(3,4-dichloro-phenyl)-piperid...)copy SMILEScopy InChI
Affinity DataIC50: 389nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070351(1-(1-{3-[1-Benzoyl-3-(3,4-dichloro-phenyl)-piperid...)copy SMILEScopy InChI
Affinity DataIC50: 460nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070355(3-(3,4-dichlorophenyl)-3-{3-[1-methylsulfonylspiro...)copy SMILEScopy InChI
Affinity DataIC50: 497nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070353(1-(1-{3-[1-Benzyl-3-(3,4-dichloro-phenyl)-6-oxo-pi...)copy SMILEScopy InChI
Affinity DataIC50: 539nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070353(1-(1-{3-[1-Benzyl-3-(3,4-dichloro-phenyl)-6-oxo-pi...)copy SMILEScopy InChI
Affinity DataIC50: 743nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070352(1-benzyl-5-(3,4-dichlorophenyl)-5-{3-[1-methylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 763nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070358(8-{3-[1-Benzyl-3-(3,4-dichloro-phenyl)-6-oxo-piper...)copy SMILEScopy InChI
Affinity DataIC50: 892nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50070356(5-[3-(4-Acetyl-4-phenyl-piperidin-1-yl)-propyl]-1-...)copy SMILEScopy InChI
Affinity DataIC50: 1.03E+3nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50001447(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)copy SMILEScopy InChI
Affinity DataEC50:  53nMAssay Description:Compound was evaluated in vitro for the inhibition of dog liver squalene epoxidase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50079412((NKB)Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 |...)copy SMILEScopy InChI
Affinity DataEC50:  6nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50001450((SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH...)copy SMILEScopy InChI
Affinity DataEC50:  793nMAssay Description:Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp Laboratory

Curated by ChEMBL
LigandPNGBDBM50052524((S)-N-((S)-1-{[(S)-1-({[(S)-1-((S)-1-Carbamoyl-3-m...)copy SMILEScopy InChI
Affinity DataEC50:  7nMAssay Description:Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3N16PubMed
* indicates data uncertainty>20%