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Target
Ubiquitin carboxyl-terminal hydrolase 1
Ligand
BDBM522936
Substrate
n/a
Meas. Tech.
HTS Assay
IC50
125±n/a nM
Citation
 Buckmelter, AJ; Ioannidis, S; Follows, B; Gustafson, G; Wang, M; Caravella, JA; Wang, Z; Fritzen, EL; Lin, J Purinones as ubiquitin-specific protease 1 inhibitors US Patent  US11161848 Publication Date 11/2/2021
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 1
Synonyms:
Deubiquitinating enzyme 1 | UBP1_HUMAN | USP1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48  | Ubiquitin thioesterase 1 | Ubiquitin-specific-processing protease 1 | hUBP
Type:
PROTEIN
Mol. Mass.:
88191.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104169
Residue:
785
Sequence:
MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQVVPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPKEEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQTRSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGKITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKVTDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNKKNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSDQTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKKL
  
Inhibitor
Name:
BDBM522936
Synonyms:
9-((1-(2,5-dimethylthiazol-4-yl)piperidin-4- | US11161848, Compound I-494
Type:
Small organic molecule
Emp. Form.:
C28H35N5O
Mol. Mass.:
457.6104
SMILES:
CC(C)c1ccccc1-c1ncc2n(C)c(=O)n(CC3CCC(CC3)C3=C(C)CC(C)=N3)c2n1 |c:27,32,(-6.59,17.65,;-7.93,16.88,;-9.26,17.65,;-7.93,15.34,;-9.26,14.57,;-9.26,13.03,;-7.93,12.26,;-6.59,13.03,;-6.59,14.57,;-5.26,15.34,;-5.26,16.88,;-3.92,17.65,;-2.59,16.88,;-1.13,17.35,;-.65,18.82,;-.22,16.11,;1.32,16.11,;-1.13,14.86,;-.65,13.4,;.86,13.08,;1.33,11.61,;2.84,11.29,;3.87,12.44,;3.39,13.9,;1.89,14.22,;5.37,12.12,;6,10.71,;5.23,9.38,;7.53,10.87,;7.85,12.38,;9.26,13,;6.52,13.15,;-2.59,15.34,;-3.92,14.57,)|
Structure:
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