Reaction Details  Report a problem with these data
Target
Macrophage colony-stimulating factor 1 receptor
Ligand
BDBM525765
Substrate
n/a
Meas. Tech.
LanthaScreen Eu Kinase Binding Assay
IC50
8.00±n/a nM
Citation
 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J Heterocyclic compounds as kinase inhibitors US Patent  US11174252 Publication Date 11/16/2021
Target
Name:
Macrophage colony-stimulating factor 1 receptor
Synonyms:
CSF1R | CSF1R_HUMAN | FMS | Fms proto-oncogene | Macrophage colony stimulating factor receptor | Macrophage colony-stimulating factor 1 receptor (FMS) | Macrophage colony-stimulating factor 1 receptor (c-FMS) | Macrophage colony-stimulating factor 1 receptor (cFMS) | Proto-oncogene c-Fms | Tyrosine Kinase CSF1-R | c-fms | cFMS
Type:
Protein
Mol. Mass.:
107979.48
Organism:
Homo sapiens (Human)
Description:
P07333
Residue:
972
Sequence:
MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC
  
Inhibitor
Name:
BDBM525765
Synonyms:
US11174252, Compound 452
Type:
Small organic molecule
Emp. Form.:
C24H28F2N6O2
Mol. Mass.:
470.5149
SMILES:
CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cnn(c2)C2CCC(O)CC2)ncc1F |(10.16,-3.47,;8.83,-2.69,;7.49,-3.47,;8.83,-1.15,;10.16,-.38,;10.16,1.15,;8.83,1.93,;7.49,1.15,;6.16,1.93,;6.16,3.47,;4.83,1.15,;4.83,-.38,;6.16,-1.15,;7.49,-.38,;3.49,-1.15,;2.16,-.38,;.83,-1.15,;-.51,-.38,;-1.84,-1.15,;-1.84,-2.69,;-3.31,-3.17,;-4.21,-1.93,;-3.31,-.68,;-5.7,-1.53,;-6.1,-.04,;-7.59,.36,;-8.67,-.73,;-10.16,-.33,;-8.28,-2.22,;-6.79,-2.62,;.83,-2.69,;2.16,-3.47,;3.49,-2.69,;4.83,-3.47,)|
Structure:
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