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Target
Vasopressin V1a receptor
Ligand
BDBM526782
Substrate
n/a
Meas. Tech.
Vasopressin V1A Receptor Antagonist Assay
IC50
<100±n/a nM
Citation
 Jones, RM; Urbano, M; Brandt, G; Hardick, D; Knight, C; Tierney, J Vasopressin receptor antagonists and products and methods related thereto US Patent  US11186577 Publication Date 11/30/2021
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM526782
Synonyms:
US11186577, Cmpd. No. 163 | US11186577, Cmpd. No. 163A | US11186577, Cmpd. No. 163B
Type:
Small organic molecule
Emp. Form.:
C26H28ClFN6O2
Mol. Mass.:
510.991
SMILES:
CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C1C)C1CC2(C1)CN(C2)c1ccc(F)cn1
Structure:
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