Reaction Details  Report a problem with these data
Target
Polycomb protein EED
Ligand
BDBM291813
Substrate
n/a
Meas. Tech.
ELISA (H3K27 Methylation) Assay
IC50
3.70±n/a nM
Citation
 Chan, HM; Gu, XJ; Huang, Y; Li, L; Mi, Y; Qi, W; Sendzik, M; Sun, Y; Wang, L; Yu, Z; Zhang, H; Zhang, JY; Zhang, M; Zhang, Q; Zhao, K Triazolopyrimidine compounds and uses thereof US Patent  US11207325 Publication Date 12/28/2021
Target
Name:
Polycomb protein EED
Synonyms:
EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED
Type:
Protein
Mol. Mass.:
50201.68
Organism:
Homo sapiens (Human)
Description:
O75530
Residue:
441
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
  
Inhibitor
Name:
BDBM291813
Synonyms:
N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methyl-4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | US11207325, Example 128 | US9580437, Example 128
Type:
Small organic molecule
Emp. Form.:
C22H20FN5O3S
Mol. Mass.:
453.489
SMILES:
Cc1cc(ccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12)S(C)(=O)=O
Structure:
Search PDB for entries with ligand similarity: