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Target
Polycomb protein EED
Ligand
BDBM291925
Substrate
n/a
Meas. Tech.
ELISA (H3K27 Methylation) Assay
IC50
1.40±n/a nM
Citation
 Chan, HM; Gu, XJ; Huang, Y; Li, L; Mi, Y; Qi, W; Sendzik, M; Sun, Y; Wang, L; Yu, Z; Zhang, H; Zhang, JY; Zhang, M; Zhang, Q; Zhao, K Triazolopyrimidine compounds and uses thereof US Patent  US11207325 Publication Date 12/28/2021
Target
Name:
Polycomb protein EED
Synonyms:
EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED
Type:
Protein
Mol. Mass.:
50201.68
Organism:
Homo sapiens (Human)
Description:
O75530
Residue:
441
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
  
Inhibitor
Name:
BDBM291925
Synonyms:
N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(1H-imidazol-1-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | US11207325, Example 240 | US9580437, Example 240
Type:
Small organic molecule
Emp. Form.:
C17H14FN7O
Mol. Mass.:
351.3378
SMILES:
Fc1ccc2OCCc2c1CNc1ncc(-n2ccnc2)c2nncn12
Structure:
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