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Target
Uromodulin
Ligand
BDBM534911
Substrate
n/a
Meas. Tech.
In-Vitro Assay
IC50
19.0±n/a nM
Citation
 Sharma, R; Iyer, P; Agarwal, S Substituted sulfoximine compounds US Patent  US11236045 Publication Date 2/1/2022
Target
Name:
Uromodulin
Synonyms:
THP | Tamm-Horsfall urinary glycoprotein | UMOD | UROM_HUMAN
Type:
Protein
Mol. Mass.:
69744.65
Organism:
Human
Description:
P07911
Residue:
640
Sequence:
MGQPSLTWMLMVVVASWFITTAATDTSEARWCSECHSNATCTEDEAVTTCTCQEGFTGDGLTCVDLDECAIPGAHNCSANSSCVNTPGSFSCVCPEGFRLSPGLGCTDVDECAEPGLSHCHALATCVNVVGSYLCVCPAGYRGDGWHCECSPGSCGPGLDCVPEGDALVCADPCQAHRTLDEYWRSTEYGEGYACDTDLRGWYRFVGQGGARMAETCVPVLRCNTAAPMWLNGTHPSSDEGIVSRKACAHWSGHCCLWDASVQVKACAGGYYVYNLTAPPECHLAYCTDPSSVEGTCEECSIDEDCKSNNGRWHCQCKQDFNITDISLLEHRLECGANDMKVSLGKCQLKSLGFDKVFMYLSDSRCSGFNDRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYLADEIIIRDLNIKINFACSYPLDMKVSLKTALQPMVSALNIRVGGTGMFTVRMALFQTPSYTQPYQGSSVTLSTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPHTRDSTIQVVENGESSQGRFSVQMFRFAGNYDLVYLHCEVYLCDTMNEKCKPTCSGTRFRSGSVIDQSRVLNLGPITRKGVQATVSRAFSSLGLLKVWLPLLLSATLTLTFQ
  
Inhibitor
Name:
BDBM534911
Synonyms:
N′-cyano-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)thiophene-2-sulfonimidamide | US11236045, Example 51
Type:
Small organic molecule
Emp. Form.:
C18H18N4O2S2
Mol. Mass.:
386.491
SMILES:
O=C(Nc1c2CCCc2cc2CCCc12)NS(=O)(=NC#N)c1cccs1
Structure:
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